{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:46:31Z","timestamp":1764225991641,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High positivity rate of skin phosphorylated \u03b1\u2010synuclein (P\u2010SYN) was observed in Parkinson's disease (PD). Bullous pemphigoid (BP) is one of the most common autoimmune skin diseases associated with PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our aim was to investigate whether BP patients might be a targeted risk population for the screening of skin P\u2010SYN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin P\u2010SYN expression was evaluated by immunohistochemistry in BP patients with\/without PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two BP patients with PD, 24 BP patients without PD, and seven healthy donors were enrolled. Colocalization of P\u2010SYN and PGP9.5 was found in all BP patients, but only one healthy control, whereas BP patients with PD showed higher expression than BP patients without PD (mean\u2009\u00b1\u2009standard deviation, 10.7\u2009\u00b1\u20096.7 vs. 7.3\u2009\u00b1\u20093.2; <jats:italic>P<\/jats:italic>\u2009=\u20090.027). Positive expression was mainly observed in basement membrane zone and dermis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicated BP patients might be a targeted risk population for the screening of skin P\u2010SYN, which was helpful for the detection of PD early. \u00a9 2024 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30045","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T23:44:48Z","timestamp":1730418288000},"page":"152-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skin Biopsy Detection of Phosphorylated \u03b1\u2010Synuclein in Patients of Bullous Pemphigoid with or without Parkinson's Disease"],"prefix":"10.1002","volume":"40","author":[{"given":"Shan","family":"Cao","sequence":"first","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Fang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4553-2871","authenticated-orcid":false,"given":"Yonghu","family":"Sun","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases Shandong First Medical University  Jinan China"},{"name":"Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0792"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14797"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.052"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.09.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002196"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2015.00032"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.01.034"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2014.14004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1990.tb02139.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.569446"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.12.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12960"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.30045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:05:41Z","timestamp":1760951141000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.30045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/mds.30045"],"URL":"https:\/\/doi.org\/10.1002\/mds.30045","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"type":"print","value":"0885-3185"},{"type":"electronic","value":"1531-8257"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"assertion":[{"value":"2024-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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