{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:48Z","timestamp":1786978188529,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1117037"],"award-info":[{"award-number":["1117037"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1157535"],"award-info":[{"award-number":["1157535"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1194829"],"award-info":[{"award-number":["1194829"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic musculoskeletal pain often co\u2010occurs with Parkinson's disease (PD); however, whether individuals with chronic pain have a higher risk of developing PD is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the associations between chronic pain and incident risk of three neurodegenerative parkinsonism categories including PD, multiple system atrophy (MSA), and progressive supranuclear palsy (PSP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 355,890 participants (mean [standard deviation] age, 56.51 [8.07] years, 48.40% male) who did not have parkinsonism at baseline from a population\u2010based cohort. Musculoskeletal pain in the hip, neck\/shoulder, back, knee, or \u201call over the body\u201d was assessed. Chronic pain was defined if pain lasted \u22653\u2009months. Participants were categorized into four groups: no chronic pain, having one or two, three or four sites, and pain \u201call over the body.\u201d The diagnosis of PD, MSA, and PSP used self\u2010reports, hospital records, and death registries. Multivariable\u2010adjusted Cox regression was performed for the analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a median follow\u2010up of 13.0\u2009years, 2044 participants developed PD, 77 participants developed MSA, and 126 participants developed PSP. In multivariable analyses, there was a dose\u2013response relationship between number of chronic pain sites and incident risk of PD (hazard ratio,\u20091.15; 95% confidence interval, 1.07\u20131.23). Participants with one or two pain sites and three or four pain sites had an 11% and 49% increased risk of developing PD, respectively. There were no associations between chronic pain and MSA or PSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Chronic musculoskeletal pain was independently associated with PD, suggesting that chronic pain could be used to identify individuals at risk of developing PD. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30046","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T05:14:07Z","timestamp":1730524447000},"page":"87-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chronic Musculoskeletal Pain and Risk of Incident Parkinson's Disease: A 13\u2010Year Longitudinal Study"],"prefix":"10.1002","volume":"40","author":[{"given":"Fatemeh","family":"Vazirian","sequence":"first","affiliation":[{"name":"Menzies Institute for Medical Research University of Tasmania  Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tian","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research University of Tasmania  Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-8676","authenticated-orcid":false,"family":"Jane Alty","sequence":"additional","affiliation":[{"name":"Wicking Dementia Research and Education Centre University of Tasmania  Hobart Australia"},{"name":"School of Medicine University of Tasmania  Hobart Australia"},{"name":"Department of Neurology, Royal Hobart Hospital  Hobart 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