{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:59:23Z","timestamp":1770141563828,"version":"3.49.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The age at onset (AAO) of Parkinson's disease (PD) varies widely among individuals and significantly influences disease progression and prognosis. However, few genome\u2010wide association studies (GWASs) have investigated genetic variants determining AAO, particularly in East Asian populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify single\u2010nucleotide polymorphisms (SNPs) affecting AAO of PD in Korean patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a GWAS on AAO of PD in 1048 Korean patients using sex\u2010adjusted linear regression models. Additionally, we conducted downstream analyses of our primary GWAS results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>rs2134545 demonstrated genome\u2010wide significance (\u03b2\u2009=\u2009\u22122.459; standard error\u2009[SE] =\u20090.851; <jats:italic>P<\/jats:italic>\u2009=\u20091.898\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) and is an intergenic SNP near the <jats:italic>ALCAM<\/jats:italic> gene associated with an average AAO reduction of 3.47\u2009years. Additionally, rs4366309 (<jats:italic>LYST<\/jats:italic>; <jats:italic>MIR1537<\/jats:italic>) demonstrated suggestive significance (\u03b2\u2009=\u20092.949; SE\u2009= 1.072; <jats:italic>P<\/jats:italic>\u2009=\u20098.68\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) and was associated with an average delay of 3.05\u2009years. The polygenic risk score based on known PD risk loci also affected the AAO for European and Korean PD risk loci, respectively (\u03b2\u2009=\u2009\u22120.149; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and \u03b2\u2009=\u2009\u22120.096; <jats:italic>P<\/jats:italic>\u2009=\u20090.002). However, the proportion of variance was small (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.022 and 0.009, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified a novel SNP associated with the AAO of PD near the <jats:italic>ALCAM<\/jats:italic> gene, distinct from previously reported PD risk loci. These findings need further functional validation; however, they suggest unique genetic pathways influencing the AAO of PD and highlight the need for further research in diverse populations. \u00a9 2024 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30047","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T06:25:25Z","timestamp":1730874325000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson's Disease: A Genome\u2010wide Association Study"],"prefix":"10.1002","volume":"40","author":[{"given":"Yun Su","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Neurology Jeonbuk National University Medical School and 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College of Medicine  Gangneung South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunsoon","family":"Shin","sequence":"additional","affiliation":[{"name":"DNA Link  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YoonGi","family":"Park","sequence":"additional","affiliation":[{"name":"DNA Link  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunji","family":"Seo","sequence":"additional","affiliation":[{"name":"DNA Link  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-0952","authenticated-orcid":false,"given":"Kyum\u2010Yil","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology Soonchunhyang University Seoul Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of 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