{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:47:17Z","timestamp":1784742437526,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["09150162010183"],"award-info":[{"award-number":["09150162010183"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013301","name":"Parkinson's Foundation","doi-asserted-by":"publisher","award":["PF\u2010FBS\u20102026"],"award-info":[{"award-number":["PF\u2010FBS\u20102026"]}],"id":[{"id":"10.13039\/100013301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. 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Previous studies on microbiota\u2010derived metabolites in PD were small\u2010scale and post\u2010diagnosis, raising concerns about reverse causality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our goal was to prospectively investigate the association between plasma microbial metabolites and PD risk within a metabolomics framework.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nested case\u2013control study within the prospective EPIC4PD cohort, measured pre\u2010diagnostic plasma microbial metabolites using untargeted metabolomics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen microbial metabolites were identified nominally associated with PD risk (<jats:italic>P<\/jats:italic>\u2010value\u2009&lt;\u20090.05), including amino acids, bile acid, indoles, and hydroxy acid, although none remained significant after multiple testing correction. Three pathways were implicated in PD risk: valine, leucine, and isoleucine degradation, butanoate metabolism, and propanoate metabolism. PD\u2010associated microbial pathways were more pronounced in men, smokers, and overweight\/obese individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Changes in microbial metabolites may represent a pre\u2010diagnostic feature of PD. We observed biologically plausible associations between microbial pathways and PD, potentially influenced by individual characteristics. \u00a9 2024 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30054","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T07:09:42Z","timestamp":1731395382000},"page":"556-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gut Microbial Metabolites and Future Risk of Parkinson's Disease: A Metabolome\u2010Wide Association Study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-0036","authenticated-orcid":false,"given":"Yujia","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute for Risk Assessment Sciences Utrecht University  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