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However, studies using the <jats:sup>18<\/jats:sup>F\u2010AV\u20101451 tau tracer have shown inconsistent findings regarding both the extent and topographical distribution of tau pathology in DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our aim was to elucidate the topographical patterns of tau deposition in DLB and to investigate the <jats:italic>in vivo<\/jats:italic> pathological distinction between DLB and AD in virtue of the <jats:sup>18<\/jats:sup>F\u2010Florzolotau positron emission tomography (PET) imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study enrolled patients with DLB (n\u2009=\u200924), AD (n\u2009=\u200943), and cognitively healthy controls (n\u2009=\u200918). Clinical assessments and <jats:sup>18<\/jats:sup>F\u2010Florzolotau PET imaging were performed. <jats:sup>18<\/jats:sup>F\u2010Florzolotau binding was quantitatively assessed on PET images using standardized uptake value ratios and voxel\u2010wise analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010Florzolotau PET imaging revealed widespread tau deposition across various cortical regions in DLB, uncovering heterogeneous topographical patterns. Among patients, 54.17% showed patterns similar to AD, whereas 16.67% exhibited distinct patterns. Compared to AD, DLB exhibited a unique <jats:italic>in vivo<\/jats:italic> neuropathological profile, characterized by a lower tau protein burden, heterogeneous topographical distributions, and a specific role of the medial temporal lobe in tau pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010Florzolotau PET imaging elucidated tau pathology patterns in DLB, providing valuable insights for future <jats:italic>in vivo<\/jats:italic> pathological differentiation and potential disease\u2010modifying therapies. \u00a9 2024 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30055","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T09:04:32Z","timestamp":1731920672000},"page":"108-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp><sup>18<\/sup>F<\/scp>\u2010Florzolotau <scp>PET<\/scp> Imaging Unveils Tau Pathology in Dementia with Lewy Bodies"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0494-3597","authenticated-orcid":false,"given":"Gan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology National Research Center for Aging and Medicine, National Center for Neurological Disorders, and State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University  Shanghai 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