{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:34Z","timestamp":1786978174230,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU23J\u201004\u201000005"],"award-info":[{"award-number":["NU23J\u201004\u201000005"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LM2023049"],"award-info":[{"award-number":["LM2023049"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although neuromelanin\u2010sensitive magnetic resonance imaging (NM\u2010MRI) has been used to evaluate early neurodegeneration in Parkinson's disease, studies concentrating on the locus coeruleus (LC) in pre\u2010dementia stages of dementia with Lewy bodies (DLB) are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aims were to evaluate NM\u2010MRI signal changes in the LC in patients with mild cognitive impairment with Lewy bodies (MCI\u2010LB) compared to healthy controls (HC) and to identify the cognitive correlates of the changes. We also aimed to test the hypothesis of a caudal\u2010rostral \u03b1\u2010synuclein pathology spread using NM\u2010MRI of the different LC subparts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 38 MCI\u2010LB patients and 59 HCs underwent clinical and cognitive testing and NM\u2010MRI of the LC. We calculated the contrast ratio of NM\u2010MRI signal (LC\u2010CR) in the whole LC as well as in its caudal, middle, and rostral MRI slices, and we compared the LC\u2010CR values between the MCI\u2010LB and HC groups. Linear regression analyses were performed to assess the relationship between the LC\u2010CR and cognitive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The MCI\u2010LB group exhibited a significant reduction in the right LC\u2010CR compared to HCs (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.021). The right LC\u2010CR decrease was associated with impaired visuospatial memory in the MCI\u2010LB group. Only the caudal part of the LC exhibited significant LC\u2010CR decreases in MCI\u2010LB patients compared to HCs on both sides (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This is the first study that focuses on LC\u2010CRs in MCI\u2010LB patients and analyzes the LC subparts, offering new insights into the LC integrity alterations in the initial stages of DLB and their clinical correlates. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  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