{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:43:48Z","timestamp":1792532628657,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u2010142345"],"award-info":[{"award-number":["MOP\u2010142345"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depression is a common nonmotor complication in Parkinson's disease (PD). However, few studies have evaluated the efficacy of first\u2010line psychological therapies for depression in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This randomized controlled trial evaluated the efficacy of interpersonal psychotherapy (IPT), an empirically validated intervention for depression that focuses on the bidirectional relationship between mood disturbance and interpersonal and social stressors. A secondary aim was to assess maintenance of treatment gains at 6\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants with PD stages I to III and a comorbid depressive disorder were randomly assigned to 12 sessions of IPT (n\u2009=\u200932) or supportive therapy (ST) (n\u2009=\u200931), our active control intervention. The primary outcome was the Hamilton Depression Rating Scale (HAM\u2010D) administered blindly by telephone. Secondary outcomes included self\u2010report depression and anxiety, quality of life, clinician\u2010rated motor symptom, interpersonal relationships, and attachment style.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IPT compared to ST resulted in a greater reduction in posttreatment HAM\u2010D scores (least square mean difference\u2009=\u2009\u22123.77, 95% confidence interval [CI]: \u22126.19 to \u22121.34,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003) and was associated with a greater odds of meeting remission (odds ratio\u2009=\u20093.23, 95% CI: 1.10\u20139.51,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.034). The advantage of IPT over ST on HAM\u2010D scores and remission rates was not sustained at the 6\u2010month follow\u2010up. Both treatments improved self\u2010report depression, anxiety, quality of life, and aspects of interpersonal functioning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This trial demonstrates the benefits of acute treatment with IPT in reducing depressive symptoms in PD. Clinicians should consider psychotherapy, alone or in combination with medication, as an important treatment option for PD depression. \u00a9 2024 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30061","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:17:26Z","timestamp":1732079846000},"page":"1539-1550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interpersonal Psychotherapy for the Treatment of Depression in Parkinson's Disease: Results of a Randomized Controlled Trial"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6040-550X","authenticated-orcid":false,"given":"Diana","family":"Koszycki","sequence":"first","affiliation":[{"name":"Counselling Psychology, Faculty of Education, University of Ottawa  Ottawa Ontario Canada"},{"name":"Department of Psychiatry University of Ottawa  Ottawa Ontario Canada"},{"name":"Institut du Savoir Montfort, Montfort Hospital  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Taljaard","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Insitute  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bradwejn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Ottawa  Ottawa Ontario Canada"},{"name":"Department of Psychiatry University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Lee","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Insitute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio A.","family":"Tasca","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Insitute  Ottawa Ontario Canada"},{"name":"School of Psychology University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Insitute  Ottawa Ontario Canada"},{"name":"Division of Neurology, Department of Medicine Faculty of Medicine, University of Ottawa  Ottawa Ontario 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