{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:16:38Z","timestamp":1787242598690,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007707","name":"Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapid eye movement (REM) sleep behavior disorder (RBD) may precede motor symptoms in Parkinson's disease (PD) by years. According to a recent hypothesis, premotor RBD (pRBD) is a marker of the PD body\u2010first subtype, where synucleinopathy originates from the peripheral autonomic nervous system. Conversely, in the brain\u2010first subtype, pathology would arise in the brain. Functional connectivity (FC) could provide additional insight into the neurodegenerative process of these putative PD subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      We aim to analyze the possible FC differences between early\u2010stage PD patients with (PD\n                      <jats:sup>pRBD+<\/jats:sup>\n                      ) and without (PD\n                      <jats:sup>pRBD\u2212<\/jats:sup>\n                      ) pRBD using high\u2010density electroencephalography (EEG).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 28 PD\n                      <jats:sup>pRBD+<\/jats:sup>\n                      , 35 PD\n                      <jats:sup>pRBD\u2212<\/jats:sup>\n                      , and 35 healthy controls (HC). Data were recorded with a 64\u2010channel EEG system, and a source\u2010reconstruction method was used to identify brain\u2010region activity. FC was calculated using the weighted phase\u2010lag index in \u03b8, \u03b1, \u03b2, and low\u2010\u03b3 bands. Statistical analysis was conducted using network\u2010based statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found a significant trend of decreased \u03b1\u2010FC across PD\n                      <jats:sup>pRBD+<\/jats:sup>\n                      , PD\n                      <jats:sup>pRBD\u2212<\/jats:sup>\n                      , and HC, mainly in prefrontal and temporal areas. The altered \u03b1\u2010FC correlated with Montreal Cognitive Assessment scores in PD\n                      <jats:sup>pRBD+<\/jats:sup>\n                      and, to a lesser extent, PD\n                      <jats:sup>pRBD\u2212<\/jats:sup>\n                      and with gait\/postural disturbances in PD\n                      <jats:sup>pRBD+<\/jats:sup>\n                      patients only. PD\n                      <jats:sup>pRBD+<\/jats:sup>\n                      and PD\n                      <jats:sup>pRBD\u2212<\/jats:sup>\n                      had similarly increased FC than HC in a \u03b2 band network, predominantly involving sensorimotor and limbic areas. The increased \u03b2 network FC was related to bradykinesia severity in both PD subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Compared to PD\n                      <jats:sup>pRBD\u2212<\/jats:sup>\n                      (brain\u2010first subtype), PD\n                      <jats:sup>pRBD+<\/jats:sup>\n                      group (body\u2010first subtype) demonstrates specific EEG\u2010FC dysfunctions in the \u03b1 band, which may reflect early involvement of the cholinergic ascending system. \u00a9 2024 International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  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