{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:09:47Z","timestamp":1791918587403,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3N0331"],"award-info":[{"award-number":["CMRPG3N0331"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3N0341"],"award-info":[{"award-number":["CMRPG3N0341"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with Parkinson's disease (PD) present progressive deterioration in both motor and non\u2010motor manifestations. However, the absence of clinical biomarkers for disease progression hinders clinicians from tailoring treatment strategies effectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify electroencephalography (EEG) biomarker that can track disease progression in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 116 patients with PD were initially enrolled, whereas 63 completed 2\u2010year follow\u2010up evaluation. Fifty\u2010eight age\u2010 and sex\u2010matched healthy individuals were recruited as the control group. All participants underwent EEG and clinical assessments. Long\u2010range temporal correlations (LRTC) of EEG data were analyzed using the detrended fluctuation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with PD exhibited higher LRTC in left parietal \u03b8 oscillations (<jats:italic>P<\/jats:italic>\u2009=\u20090.0175) and lower LRTC in centro\u2010parietal \u03b3 oscillations (<jats:italic>P<\/jats:italic>\u2009=\u20090.0258) compared to controls. LRTC in parietal \u03b3 oscillations inversely correlated with changes in Unified Parkinson's Disease Rating Scale (UPDRS) part III scores over 2\u2009years (Spearman \u03c1\u2009=\u2009\u22120.34, <jats:italic>P<\/jats:italic>\u2009=\u20090.0082). Increased LRTC in left parietal \u03b8 oscillations were associated with rapid motor progression (<jats:italic>P<\/jats:italic>\u2009=\u20090.0107), defined as an annual increase in UPDRS part III score\u2009\u22653. In cognitive assessments, LRTC in parieto\u2010occipital \u03b1 oscillations exhibited a positive correlation with changes in Mini\u2010Mental State Examination and Montreal Cognitive Assessment scores over 2\u2009years (Spearman \u03c1\u2009=\u20090.27\u20130.38, <jats:italic>P<\/jats:italic>\u2009=\u20090.0037\u20130.0452).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LRTC patterns in EEG potentially predict rapid progression of both motor and non\u2010motor manifestations in PD patients, enhancing clinical assessment and understanding of the disease. \u00a9 2024 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30074","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T02:29:46Z","timestamp":1733970586000},"page":"266-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010Range Temporal Correlations in Electroencephalography for Parkinson's Disease Progression"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-1669","authenticated-orcid":false,"given":"Chih\u2010Hong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center Chang Gung University College of Medicine  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Hung","family":"Juan","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Neuroscience National Central University  Taoyuan Taiwan"},{"name":"Cognitive Intelligence and Precision Healthcare Research Center National Central University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang\u2010Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Information Engineering National Taiwan Normal University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Pei","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center Chang Gung University College of Medicine  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-0609","authenticated-orcid":false,"given":"Isobel","family":"French","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Neuroscience National Central University  Taoyuan Taiwan"},{"name":"Cognitive Intelligence and Precision Healthcare Research Center National Central University  Taoyuan 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