{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:56:01Z","timestamp":1792803361552,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Essential tremor (ET) is characterized by action tremor of the arms, which can interfere substantially with daily activities. Pharmacotherapy may be ineffective or associated with side effects, and stereotactic surgery is invasive. Hence, new accessible treatment options are urgently needed. An easy\u2010to\u2010use and lightweight orthotic device that exerts joint damping may provide an alternative solution for reducing tremor in daily activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our goal was to assess the efficacy of a novel anti\u2010tremor orthosis (STIL) in reducing clinical and accelerometry measures of distal arm tremor in ET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomized crossover single\u2010blinded trial in 24 ET patients in a hospital setting, we compared three conditions: no orthosis (baseline), a sham device, and the anti\u2010tremor orthosis (order randomized). The orthosis, but not the sham device, passively damped joints in the forearm. Participants performed seven tasks from the Tremor Research Group Essential Tremor Rating Scale (TETRAS). The two co\u2010primary outcome measures were: clinical tremor severity (video\u2010scored TETRAS) and tremor power (accelerometry). Patient satisfaction was self\u2010assessed using the Dutch Quebec User Evaluation of Satisfaction with assistive Technology. Conditions were compared using Wilcoxon signed\u2010rank tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The anti\u2010tremor orthosis significantly reduced TETRAS scores compared to sham and baseline (baseline: 19.0\u2009\u00b1\u20093.2, sham: 13.7\u2009\u00b1\u20093.9, orthosis: 9.9\u2009\u00b1\u20093.6; mean\u2009\u00b1 standard deviation). Similar effects were observed for tremor power, which was reduced by 87.4% (orthosis vs. baseline) and 59.5% (orthosis vs. sham) across all tasks. A total of 71% of participants were (very) satisfied and 12.5% reported minor adverse events (discomfort\/redness of skin).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The anti\u2010tremor orthosis had a clinically relevant tremor\u2010reducing effect in ET in a controlled setting, offering potential for a new treatment to manage ET in daily activities. \u00a9 2025 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30082","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T01:21:21Z","timestamp":1737508881000},"page":"445-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Essential Tremor Suppression with a Novel Anti\u2010Tremor Orthosis: A Randomized Crossover Trial"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6071-6401","authenticated-orcid":false,"given":"Winfred","family":"Mugge","sequence":"first","affiliation":[{"name":"Faculty of Mechanical Engineering, Department of Biomechanical Engineering Delft University of Technology  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6283-4719","authenticated-orcid":false,"given":"Liset E.M.","family":"Elstgeest","sequence":"additional","affiliation":[{"name":"Reinier de Graaf Hospital, Reinier Academy  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"van Ginkel","sequence":"additional","affiliation":[{"name":"Department of Neurology Reinier de Graaf Hospital  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Pol","sequence":"additional","affiliation":[{"name":"Department of Neurology Reinier de Graaf Hospital  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IJsbrand","family":"de Lange","sequence":"additional","affiliation":[{"name":"Department of Research and Development STIL B.V  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Pambakian","sequence":"additional","affiliation":[{"name":"Department of Research and Development STIL B.V  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0340-3162","authenticated-orcid":false,"given":"Alvaro","family":"Assis de Souza","sequence":"additional","affiliation":[{"name":"Department of Research and Development STIL B.V  Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-6573","authenticated-orcid":false,"given":"Rick C.","family":"Helmich","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain, Cognition and Behaviour, Centre of Expertise for Parkinson and Movement Disorders, Department of Neurology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-6597","authenticated-orcid":false,"given":"Daan J.","family":"Kamphuis","sequence":"additional","affiliation":[{"name":"Department of Neurology Reinier de Graaf Hospital  Delft The 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