{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:51:16Z","timestamp":1790711476720,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102023\u201000265820"],"award-info":[{"award-number":["RS\u20102023\u201000265820"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2018IP0622"],"award-info":[{"award-number":["2018IP0622"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mitochondrial function influences Parkinson's disease (PD) through the accumulation of pathogenic alpha\u2010synuclein, oxidative stress, impaired autophagy, and neuroinflammation. The mitochondrial DNA copy number (mtDNA\u2010CN), representing the number of mitochondrial DNA copies within a cell, serves as an easily assessable proxy for mitochondrial function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess the diagnostic and prognostic capabilities of mtDNA\u2010CN in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed mtDNA\u2010CN in blood samples using whole genome sequencing from 405 patients with PD and 200 healthy controls (HC). We examined the relationship between mtDNA\u2010CN levels and motor symptom severity in PD, as well as their association with dementia development in patients with early\u2010PD (within 3\u2009years of diagnosis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>mtDNA\u2010CN levels were significantly lower in patients with PD compared with HC (<jats:italic>P<\/jats:italic>\u2009=\u20091.1\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>). A negative correlation was discovered between mtDNA\u2010CN level and motor severity in PD (correlation coefficient\u2009=\u2009\u22120.20; <jats:italic>P<\/jats:italic>\u2009=\u20090.008). Among 210 patients with early\u2010PD, Cox regression analysis demonstrated an association between lower mtDNA\u2010CN levels and a higher risk of developing dementia (hazard ratio [HR]\u2009=\u20090.41, 95% confidence interval: 0.20\u20130.86, <jats:italic>P<\/jats:italic>\u2009=\u20090.02), even after adjusting for age and blood cell count (HR\u2009=\u20090.41, 95% confidence interval: 0.18\u20130.92, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). However, mtDNA\u2010CN levels did not significantly correlate with motor progression in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that blood mtDNA\u2010CN may function as a diagnostic biomarker for PD and a prognostic marker for dementia in patients with PD. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30098","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T08:48:53Z","timestamp":1736153333000},"page":"502-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mitochondrial <scp>DNA<\/scp> Copy Number as a Potential Biomarker for the Severity of Motor Symptoms and Prognosis in Parkinson's Disease"],"prefix":"10.1002","volume":"40","author":[{"given":"Sungyang","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Neurology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hye","family":"Oh","sequence":"additional","affiliation":[{"name":"Bioinformatics Core Laboratory, Convergence Medicine Research Center Asan Institute for Life Sciences, Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moongwan","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Department of Neurology Chung\u2010Ang University Hospital, Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Ohk","family":"Sung","sequence":"additional","affiliation":[{"name":"Bioinformatics Core Laboratory, Convergence Medicine Research Center Asan Institute for Life Sciences, Asan Medical Center  Seoul Republic of Korea"},{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-8233","authenticated-orcid":false,"given":"Sun Ju","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of 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