{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:20:09Z","timestamp":1791580809721,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The recent Movement Disorders Society (MDS)\u2010progressive supranuclear palsy (PSP) diagnostic criteria conceptualized three clinical diagnostic certainty levels: \u201csuggestive of PSP\u201d for sensitive early diagnosis based on subtle clinical signs, \u201cpossible PSP\u201d balancing sensitivity and specificity, and \u201cprobable PSP\u201d highly specific for PSP pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to prospectively validate the criteria against long\u2010term clinical follow\u2010up and characterize the diagnostic certainty increase over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with \u201cpossible PSP\u201d or \u201csuggestive of PSP\u201d diagnosis and clinical follow\u2010up were recruited in two German multicenter longitudinal observational studies (ProPSP and DescribePSP). The cumulative percentage of patients longitudinally increasing diagnostic certainty was assessed over up to 2.5\u2009years of follow\u2010up. The sample size per arm required to detect 30% attenuated rate in diagnostic certainty increase in trials was estimated over multiple time intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 254 patients with available longitudinal data, 61 patients had low diagnostic certainty at baseline (48 suggestive of PSP, 13 possible PSP) and multiple clinical visits (median: 3, range: 2\u20134). The cumulative percentage of patients increasing diagnostic certainty progressed with follow\u2010up duration (30.4% at 6\u2009months, 51.7% at 1\u2009year, 80.4% at 2.5\u2009years). The sample size required to detect 30% reduction in diagnostic certainty increase rate within 1\u2009year was 163, slightly smaller than that required using the PSP rating scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Most \u201csuggestive of PSP\u201d patients increased diagnostic certainty upon longitudinal follow\u2010up, providing the first prospective multicenter validation of MDS\u2010PSP diagnostic criteria. Our data support the design of trials tailored for these early\u2010stage patients, suggesting the PSP rating scale and the diagnostic certainty increase rate as potential endpoint measures. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30112","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T02:33:44Z","timestamp":1736562824000},"page":"526-536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prospective Multicenter Evaluation of the\n                    <scp>MDS<\/scp>\n                    \u201cSuggestive of\n                    <scp>PSP<\/scp>\n                    \u201d Diagnostic Criteria"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-2083","authenticated-orcid":false,"given":"Andrea","family":"Quattrone","sequence":"first","affiliation":[{"name":"Department of Neurology LMU University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen  Munich Germany"},{"name":"Department of Medical and Surgical Sciences, Institute of Neurology Magna Graecia University  Catanzaro Italy"},{"name":"Neuroscience Research Centre Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Franzmeier","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD) University Hospital, LMU  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"},{"name":"Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, Institute of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor C.","family":"Petzold","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"},{"name":"Department of Vascular Neurology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Spottke","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"},{"name":"Department of Vascular Neurology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Brosseron","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Falkenburger","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Dresden Germany"},{"name":"Department of Neurology University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Prudlo","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Rostock\u2010Greifswald Germany"},{"name":"Department of Neurology University Medical Centre  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gasser","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"},{"name":"Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The DESCRIBE\u2010PSP Group, The ProPSP Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter U.","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Munich  Munich 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