{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:37:40Z","timestamp":1790008660755,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1261 T1"],"award-info":[{"award-number":["SFB 1261 T1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 295"],"award-info":[{"award-number":["TRR 295"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pallidal neurostimulation is an effective treatment for severe isolated dystonia, but long\u2010term data from clinical trials are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate long\u2010term efficacy and safety of pallidal neurostimulation in patients with isolated generalized or segmental dystonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Extension study of the prospective multicenter trial (n\u2009=\u200940; July 2002 to May 2004), all patients received effective stimulation and underwent regular follow\u2010up. The 10\u2010year follow\u2010up (n\u2009=\u200931) included Burke\u2013Fahn\u2013Marsden Dystonia Rating Scale (BFMDRS) motor and disability score, Beck Depression Inventory, Beck Anxiety Inventory, and Mattis Dementia Rating Scale. Primary and secondary endpoints compared motor symptoms, disability scores, mood, and cognition changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010one patients (12 female), aged 23\u201372\u2009years, completed the 10\u2010year study extension. Per protocol analysis showed sustained significant improvement in BFMDRS motor scores at 10\u2009years compared with baseline, without significant change from the 6\u2010month or 5\u2010year follow\u2010up. On average, motor scores decreased by 25.3\u2009\u00b1\u20095.2 points at 10\u2009years (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001; 56% improvement). Individual outcomes varied, with 27 responders (\u226525% improvement; mean improvement 65.2\u2009\u00b1\u200921.4%) and 13 non\u2010responders compared with baseline. Sustained improvements were seen in disability, mood, and anxiety scores. Cognition remained stable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study presents the longest prospective, multicenter follow\u2010up of pallidal neurostimulation in generalized and segmental dystonia. Two\u2010thirds of patients showed strong and stable long\u2010term improvements of dystonia, confirming sustained efficacy and safety over 10\u2009years in treatment\u2010refractory dystonic patients. However, one\u2010third experienced primary (3\/40) or secondary (10\/40) treatment failure. Diagnostic advances, including genetic testing, and technological progress in pallidal neurostimulation may help to reduce the non\u2010responder rates in the future. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30130","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T08:24:35Z","timestamp":1738743875000},"page":"1098-1111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Long\u2010Term Outcomes on Pallidal Neurostimulation for Dystonia: A Controlled, Prospective 10\u2010Year 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