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This MDSGene systematic literature review covers 27,963 patients carrying\n                    <jats:italic>GBA1<\/jats:italic>\n                    variants from 1082 publications with 794 variants, including 13,342 patients with PD or other forms of parkinsonism. It provides a comprehensive overview of demographic, clinical, and genetic findings from an ethnically diverse sample originating from 82 countries across five continents. The most frequent pathogenic or likely pathogenic variants were \u201cN409S\u201d (aka \u201cN370S\u201d; dominating among Jewish and Whites), and \u201cL483P\u201d (aka \u201cL444P\u201d; dominating among Asians and Hispanics), whereas the most common coding risk variants were \u201cE365K\u201d (E326K), and \u201cT408M\u201d (T369M) (both common among Whites). A novel finding is that early\u2010onset PD patients were predominantly of Asian ethnicity, whereas late\u2010onset PD patients were mainly of White ethnicity. Motor cardinal features were similar between PD patients and other forms of parkinsonism, whereas motor complications and non\u2010motor symptoms were more frequently reported in PD patients carrying \u201csevere\u201d variants than in those with \u201crisk\u201d or \u201cmild\u201d variants. Cognitive decline was reported in most patients after surgical treatment, despite achieving a beneficial motor function response. Most GD patients developing PD harbored the \u201cN409S\u201d variant, were of Ashkenazi Jewish ethnicity, and showed a positive response to chronic levodopa treatment. With this review, we start to fill the gaps regarding genotype\u2013phenotype correlations in\n                    <jats:italic>GBA1<\/jats:italic>\n                    variant carriers, especially concerning PD. \u00a9 2025 The Author(s).\n                    <jats:italic>Movement Disorders<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                  <\/jats:p>","DOI":"10.1002\/mds.30141","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T23:32:14Z","timestamp":1739230334000},"page":"605-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Classification and Genotype\u2013Phenotype Relationships of\n                    <scp>\n                      <i>GBA1<\/i>\n                    <\/scp>\n                    Variants:\n                    <scp>MDSGene<\/scp>\n                    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