{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:41:21Z","timestamp":1781091681886,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN214122"],"award-info":[{"award-number":["IN214122"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001079"],"award-info":[{"award-number":["UL1TR001079"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS056307"],"award-info":[{"award-number":["R01NS056307"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["A1\u2010S\u201010669"],"award-info":[{"award-number":["A1\u2010S\u201010669"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["4414096270"],"award-info":[{"award-number":["4414096270"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DE 256\/1\u20101"],"award-info":[{"award-number":["DE 256\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TI 239\/17\u20101"],"award-info":[{"award-number":["TI 239\/17\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01DN18022"],"award-info":[{"award-number":["01DN18022"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GQ1402"],"award-info":[{"award-number":["01GQ1402"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["CRC\u20102020\u201000079"],"award-info":[{"award-number":["CRC\u20102020\u201000079"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["EEC\u20101460674"],"award-info":[{"award-number":["EEC\u20101460674"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002243","name":"National Ataxia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102022\u201003368"],"award-info":[{"award-number":["RGPIN\u20102022\u201003368"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Spinocerebellar ataxia type 2 (SCA2) is a rare, inherited neurodegenerative disease characterized by progressive deterioration in both motor coordination and cognitive function. Atrophy of the cerebellum, brainstem, and spinal cord are core features of SCA2; however, the evolution and pattern of whole\u2010brain atrophy in SCA2 remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We undertook a multisite, structural magnetic resonance imaging (MRI) study to comprehensively characterize the neurodegeneration profile of SCA2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Voxel\u2010based morphometry analyses of 110 participants with SCA2 and 128 controls were undertaken to assess groupwise differences in whole\u2010brain volume. Correlations with clinical severity and genotype, and cross\u2010sectional profiling of atrophy patterns at different disease stages, were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Atrophy in SCA2 versus controls was greatest (Cohen's <jats:italic>d<\/jats:italic> &gt;2.5) in the cerebellar white matter (WM), middle cerebellar peduncle, pons, and corticospinal tract. Very large effects (<jats:italic>d<\/jats:italic> &gt;1.5) were also evident in the superior cerebellar, inferior cerebellar, and cerebral peduncles. In the cerebellar gray matter (GM), large effects (<jats:italic>d<\/jats:italic> &gt;0.8) were observed in areas related to both motor coordination and cognitive tasks. Strong correlations (|<jats:italic>r<\/jats:italic>|\u2009&gt;\u20090.4) between volume and disease severity largely mirrored these groupwise outcomes. Stratification by disease severity exhibited a degeneration pattern beginning in the cerebellar and pontine WM in preclinical subjects; spreading to the cerebellar GM and cerebro\u2010cerebellar\/corticospinal WM tracts; and then finally involving the thalamus, striatum, and cortex in severe stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The magnitude and pattern of brain atrophy evolve over the course of SCA2, with widespread, nonuniform involvement across the brainstem, cerebellar tracts, and cerebellar cortex; and late involvement of the cerebral cortex and striatum. \u00a9 2025 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30143","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T23:22:57Z","timestamp":1739229777000},"page":"651-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from <scp>ENIGMA<\/scp>\u2010Ataxia"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-0403","authenticated-orcid":false,"given":"Jason W.","family":"Robertson","sequence":"first","affiliation":[{"name":"Faculty of Computer Science Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Adanyeguh","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau, INSERM, CNRS, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Boesch","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Brunetti","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0300-5160","authenticated-orcid":false,"given":"Sirio","family":"Cocozza","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4921-2939","authenticated-orcid":false,"given":"L\u00e9o","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program of Internal Medicine, Internal Medicine Department, Hospital de Cl\u00ednicas Federal University of Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Deistung","sequence":"additional","affiliation":[{"name":"University Clinic and Outpatient Clinic for Radiology, Department for Radiation Medicine University Hospital Halle (Saale), University Medicine Halle  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Diciotti","sequence":"additional","affiliation":[{"name":"Department of Electrical, Electronic, and Information Engineering \u201cGuglielmo Marconi\u201d University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imis","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University  Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging Research Center J\u00fclich GmbH  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Durr","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau, INSERM, CNRS, AP\u2010HP  Paris France"},{"name":"Department of Genetics AP\u2010HP, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, DMU BioGeM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4038-0904","authenticated-orcid":false,"given":"Juan","family":"Fernandez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Neuropsychology Laboratory, Department of Physiology, Faculty of Medicine National Autonomous University of Mexico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia L.","family":"G\u00f6ricke","sequence":"additional","affiliation":[{"name":"Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS) Essen University Hospital, University of Duisburg\u2010Essen  Essen Germany"},{"name":"Institute of Diagnostic and Interventional Radiology and Neuroradiology Essen University Hospital, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Grisoli","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2405-3564","authenticated-orcid":false,"given":"Caterina","family":"Mariotti","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics and Neurogenetics Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Marzi","sequence":"additional","affiliation":[{"name":"Department of Statistics, Computer Science, and Applications \u201cGiuseppe Parenti\u201d University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mascalchi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Biomedical Sciences \u201cMario Serio\u201d University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Mochel","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut du Cerveau, INSERM, CNRS, AP\u2010HP  Paris France"},{"name":"Department of Genetics AP\u2010HP, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, DMU BioGeM  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Nachbauer","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Nanetti","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics and Neurogenetics Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-5458","authenticated-orcid":false,"given":"Anna","family":"Nigri","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio E.","family":"Ono","sequence":"additional","affiliation":[{"name":"Cl\u00ednica DAPI\u2014Diagn\u00f3stico Avan\u00e7ado Por Imagem  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiadi U.","family":"Onyike","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry L.","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9730-9228","authenticated-orcid":false,"given":"Kathrin","family":"Reetz","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University  Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging Research Center J\u00fclich GmbH  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Romanzetti","sequence":"additional","affiliation":[{"name":"Department of Neurology RWTH Aachen University  Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging Research Center J\u00fclich GmbH  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-6317","authenticated-orcid":false,"given":"Francesco","family":"Sacc\u00e0","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Reproductive and Odontostomatological Sciences University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases Hertie Institute for Clinical Brain Research  T\u00fcbingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio A. Ghizoni","family":"Teive","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program of Internal Medicine, Internal Medicine Department, Hospital de Cl\u00ednicas Federal University of Paran\u00e1  Curitiba Brazil"},{"name":"Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Cl\u00ednicas Federal University of Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia I.","family":"Thomopoulos","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine University of Southern California  Marina del Rey California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine University of Southern California  Marina del Rey California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Timmann","sequence":"additional","affiliation":[{"name":"Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS) Essen University Hospital, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Radiology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Harding","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"School of Translational Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-5577","authenticated-orcid":false,"given":"Carlos R.","family":"Hernandez\u2010Castillo","sequence":"additional","affiliation":[{"name":"Faculty of Computer Science Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.01.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12808"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.09.026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-011-0308-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.06.011"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.616419"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135449"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031020"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219042.60538.92"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10657"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51686"},{"issue":"10","key":"e_1_2_11_13_1","article-title":"A standardized pipeline for examining human cerebellar grey matter morphometry using structural magnetic resonance imaging","volume":"180","author":"Kerestes R","year":"2022","journal-title":"J Vis Exp"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2023.101302"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116819"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.05.056"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.01.006"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giae049"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.045"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.10.035"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.014"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0436-x"},{"issue":"1","key":"e_1_2_11_26_1","first-page":"29","article-title":"Voxel\u2010based morphometry of brain MRI in normal aging and Alzheimer's disease","volume":"4","author":"Matsuda H","year":"2013","journal-title":"Aging Dis"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.02.010"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26200"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70104-2"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1014-8"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235854"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12040601"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001711"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4343"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-023-03260-4"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089410"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.06.036"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-014-0574-3"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.504"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.06.022"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.646075"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001493"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1614-22.2022"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2614-09.2009"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26320"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.03.009"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2023.101343"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/jimaging8110303"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.30143","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.30143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:32:54Z","timestamp":1760952774000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.30143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/mds.30143"],"URL":"https:\/\/doi.org\/10.1002\/mds.30143","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]},"assertion":[{"value":"2024-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}