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A total of 916 participants were recruited in the HSPD cohort, and 171 participants were in the PPMI cohort. Longitudinal analysis examined the association between baseline APLP1 levels and PD progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant increase in APLP1 levels was observed in PD patients compared to healthy controls. Longitudinal analysis showed that patients with elevated baseline APLP1 levels experienced faster motor deterioration in HSPD cohort (HR\u2009=\u20093.627, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data indicate that APLP1 is associated with the progression of PD, potentially offering a measurable indicator of disease progression. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30154","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T07:25:56Z","timestamp":1739949956000},"page":"969-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing Plasma <scp>APLP1<\/scp> for the Progression of Parkinson's Disease: Insights from <scp>HSPD<\/scp> and <scp>PPMI<\/scp> Cohorts"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2214-9207","authenticated-orcid":false,"given":"You","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Nan","family":"Yin","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Cell\u2010based Immunotherapy of Shanghai Pudong Hospital, State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Bing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2819-6554","authenticated-orcid":false,"given":"Yi\u2010Lin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Min","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1631","authenticated-orcid":false,"given":"Feng\u2010Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Research Center for Aging and Medicine &amp; 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