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Although various candidate biomarkers have been proposed for adaptive deep brain stimulation (DBS), a comprehensive comparison of their ambulatory profiles is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To systematically compare the ambulatory neurophysiological dynamics and clinical properties of three candidate biomarkers\u2014low\u2010frequency, beta (\u03b2), and finely tuned \u03b3 (FTG) activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated 14 PD patients implanted with the Medtronic Percept PC, who underwent up to two 4\u2010week ambulatory multimodal recording periods on their regular medication and stimulation. Subthalamic nucleus local field potentials (LFPs) of low\u2010frequency, \u03b2, and FTG activity were recorded. Additionally, objective motor symptom states, physical activity and heart rate using wearables, as well as medication\u2010intake times, sleep\u2010awake times, and subjective symptom states using diaries were co\u2010registered. LFP dynamics were also compared to high\u2010resolution in\u2010hospital recordings under <jats:italic>off<\/jats:italic>\/<jats:italic>on<\/jats:italic> dopaminergic medication and stimulation conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FTG reliably indexed <jats:italic>off<\/jats:italic> to <jats:italic>on<\/jats:italic> medication states in the ambulatory setting at the group and individual levels, and these spectral dynamics could be anticipated by high\u2010resolution in\u2010hospital recordings. Both FTG and low\u2010frequency correlated with wearable\u2010based dyskinesia scores, whereas diary\u2010based dyskinesia events were only linked to FTG. Importantly, FTG indicated <jats:italic>on<\/jats:italic>\u2010medication states regardless of the presence of dyskinesia and despite potential motion and heart rate artifacts. The 24\u2010hour profile revealed large circadian power shifts that may overdrive medication\u2010intake dynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the limitations of low\u2010temporal resolution recordings, this work provides valuable insights into the real\u2010life dynamics of biomarkers. Specifically, it highlights the utility of FTG as a primary and reliable indicator of medication states for adaptive DBS. \u00a9 2025 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30160","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:38:31Z","timestamp":1741862311000},"page":"881-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Finely Tuned \u03b3 Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain\u2010Sense Study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3818-5242","authenticated-orcid":false,"given":"Aaron","family":"Colombo","sequence":"first","affiliation":[{"name":"Department of Neurology Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"ARTORG Center for Biomedical Engineering Research University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Department of Neurology Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"Graduate School of Cellular and Biomedical Sciences (GCB) University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Alva","sequence":"additional","affiliation":[{"name":"Department of Neurology Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Neurology Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-2963","authenticated-orcid":false,"given":"Ines","family":"Debove","sequence":"additional","affiliation":[{"name":"Department of Neurology Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Nowacki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Serquet","sequence":"additional","affiliation":[{"name":"Department of Neurology Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Petermann","sequence":"additional","affiliation":[{"name":"Department of Neurology Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-5035","authenticated-orcid":false,"given":"T.A. 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