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No previous studies have explored burst characteristics and coupling across the sensorimotor cortical\u2010STN circuit and determined their relationship to dynamic measurements of bradykinesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We sought to (1) establish the characteristics of sensorimotor cortical and STN bursts during naturalistic behaviors, (2) determine the predictability of STN bursts from motor cortical recordings, and (3) relate burst features to continuous measurements of bradykinesia using wearable sensors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 1046\u2009h of wirelessly streamed bilateral sensorimotor cortical and STN recordings from 5 PD patients with concurrent measurements of bradykinesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>STN bursts were longer than cortical bursts and had shorter inter\u2010burst intervals. Long bursts (&gt;200\u2009ms) in both structures displayed temporal overlap (&gt;30%), with cortical bursts tending to lead STN burst onset by 8\u2009ms. Worsening bradykinesia was linked to increased cortical burst rates and durations, whereas STN burst properties had the opposite effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cortical beta bursts tend to precede STN beta bursts with short delays and their occurrence relates to worsening bradykinesia in naturalistic settings. \u00a9 2025 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30163","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T19:02:45Z","timestamp":1740855765000},"page":"962-968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Beta Burst Characteristics and Coupling within the Sensorimotor Cortical\u2010Subthalamic Nucleus Circuit Dynamically Relate to Bradykinesia in Parkinson's Disease"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-5203","authenticated-orcid":false,"given":"Pan","family":"Yao","sequence":"first","affiliation":[{"name":"MRC Brain Network Dynamics Unit, University of Oxford  Oxford United Kingdom"},{"name":"State Key Laboratory of Transducer Technology Aerospace Information Research Institute (AIR), Chinese Academy of Sciences  Beijing China"},{"name":"School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences (UCAS)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-3386","authenticated-orcid":false,"given":"Abhinav","family":"Sharma","sequence":"additional","affiliation":[{"name":"MRC Brain Network Dynamics Unit, University of Oxford  Oxford United 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