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Here, we propose that artificial intelligence (AI) can aid in the identification and understanding of these disorders through the utilization of a smart virtual assistant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim is to develop and validate an AI\u2010powered virtual assistant for diagnosing chronic ataxias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A non\u2010commercial virtual assistant was developed using advanced algorithms, decision trees, and large language models. In the validation process, 453 clinical cases from the literature were selected from 151 causes of chronic ataxia. The diagnostic accuracy was compared with that of 21 neurologists specializing in movement disorders and GPT\u20104. Usability regarding time and number of questions needed were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The virtual assistant accuracy was 90.9%, higher than neurologists (18.3%), and GPT\u20104 (19.4%). It also significantly outperformed in causes of ataxia distributed by age, inheritance, frequency, associated clinical manifestations, and treatment availability. Neurologists and GPT\u20104 mentioned 110 incorrect diagnoses, 83.6% of which were made by GPT\u20104, which also generated seven data hallucinations. The virtual assistant required an average of 14 questions and 1.5\u2009minutes to generate a list of differential diagnoses, significantly faster than the neurologists (mean, 19.4\u2009minutes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The virtual assistant proved to be accurate and easy fast\u2010use for the diagnosis of chronic ataxias, potentially serving as a support tool in neurological consultation. This diagnostic approach could also be expanded to other neurological and non\u2010neurological diseases. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30168","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T11:11:46Z","timestamp":1742728306000},"page":"906-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Artificial Intelligence\u2010Based Virtual Assistant for the Diagnostic Approach of Chronic Ataxias"],"prefix":"10.1002","volume":"40","author":[{"given":"Lucas","family":"Alessandro","sequence":"first","affiliation":[{"name":"Departmento de Neurologia, Fleni  Buenos Aires Argentina"},{"name":"Entelai  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bianciotti","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Salama","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Volmaro","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Navarrine","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6788-3587","authenticated-orcid":false,"given":"Lucia","family":"Ameghino","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Movimientos Anormales, Departamento de Neurolog\u00eda, Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta","family":"Arena","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Movimientos Anormales, Departamento de Neurolog\u00eda, Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Bestoso","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Parkinson y Trastornos del Movimiento del Hospital Italiano Buenos Aires (HIBA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences University of Calgary Hotchkiss Brain Institute  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4727-2535","authenticated-orcid":false,"given":"Sergio","family":"Castillo Torres","sequence":"additional","affiliation":[{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Dr. Jose Eleuterio Gonzalez Universidad Aut\u00f3noma de Nuevo Leon  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Chamorro","sequence":"additional","affiliation":[{"name":"Sanatorio Parque, Servicio de Neurolog\u00eda. 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