{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:47:32Z","timestamp":1787802452825,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves Parkinson's disease (PD) motor symptoms but may deteriorate verbal fluency (VF). Theta stimulation showed potential cognitive benefits associated with motor worsening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This randomized, double\u2010blind, crossover study evaluated the efficacy and safety of combined theta\u2010gamma frequency stimulation on VF in PD patients with STN\u2010DBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomized 1:1 for standard or theta\u2010gamma stimulation. VF, motor, and non\u2010motor symptoms were assessed at baseline, 1\u2009h, and 1\u2009month after each period. Data were analyzed using a linear mixed\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients completed the study. Non\u2010episodic (<jats:italic>P<\/jats:italic>\u2009=\u20090.038) and episodic VF (<jats:italic>P<\/jats:italic>\u2009=\u20090.030) improved after 1\u2009month of theta\u2010gamma stimulation, while phonemic and switching fluency were unchanged. Motor and non\u2010motor outcomes were unaffected by the stimulation, with mild adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined theta\u2010gamma stimulation may enhance VF in PD patients with STN\u2010DBS without worsening motor symptoms or safety concerns. \u00a9 2025 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30218","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T10:09:12Z","timestamp":1746439752000},"page":"1189-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Theta\u2010Gamma Subthalamic Stimulation for Verbal Fluency in Parkinson's Disease: A Randomized, Crossover 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