{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:12:04Z","timestamp":1792260724303,"version":"4.4.0"},"reference-count":67,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["101156595"],"award-info":[{"award-number":["101156595"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With disease\u2010modifying drugs for degenerative ataxias on the horizon, ecologically valid measures of gait performance that can detect patient\u2010relevant changes in trial\u2010like time frames are highly warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In this 2\u2010year longitudinal study, we aimed to unravel ataxic gait measures sensitive to longitudinal changes in patients' real lives using wearable sensors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed longitudinal gait changes of 26 participants with degenerative cerebellar disease (Scale for the Assessment and Rating of Ataxia [SARA]: 9.4\u2009\u00b1\u20094.1) at baseline, 1\u2010year, and 2\u2010year follow\u2010up using three body\u2010worn inertial sensors in two conditions: (1) laboratory\u2010based walking (LBW); and (2) real\u2010life walking (RLW). In RLW, a context\u2010sensitive analysis was performed by selecting comparable walking bouts according to macroscopic gait characteristics. Gait analysis focused on measures of spatio\u2010temporal variability, particularly stride length variability, lateral step deviation, and a compound measure of spatial variability (SPCmp).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gait variability measures showed high test\u2013retest reliability in both walking conditions (intraclass correlation coefficient [ICC], \u22650.82). Cross\u2010sectional analyses revealed high correlations of gait measures with ataxia severity (SARA, effect size \u03c1\u2009\u2265\u20090.75); and with patients' subjective balance confidence (Activity\u2010specific Balance Confidence scale [ABC]: \u03c1\u2009\u2265\u20090.71).<\/jats:p>\n                    <jats:p>\n                      Although SARA showed longitudinal changes only after 2\u2009years, the gait measure\n                      <jats:italic>SPCmp<\/jats:italic>\n                      revealed changes after 1\u2009year with high effect size (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>prb<\/jats:sub>\n                      \u2009=\u20090.80). Sample size estimation for the gait measure SPCmp showed a required cohort size of n\u2009=\u200942 participants (n\u2009=\u200938; spinocerebellar ataxias [SCA]\n                      <jats:sub>1\/2\/3<\/jats:sub>\n                      subgroup) to detect a 50% reduction in progression at 1\u2009year with a hypothetical intervention, compared to n\u2009=\u2009147 for SARA at 2\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Because of their ecological validity and larger effect sizes, real\u2010life gait characteristics represent promising performance measures as outcomes for future treatment trials. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30230","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T04:24:02Z","timestamp":1747801442000},"page":"1343-1355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Capture of Longitudinal Change in Real\u2010Life Walking in Cerebellar Ataxia Increases Patient Relevance and Effect Size"],"prefix":"10.1002","volume":"40","author":[{"given":"Jens","family":"Seemann","sequence":"first","affiliation":[{"name":"Section Computational Sensomotorics Hertie Institute for Clinical Brain Research  T\u00fcbingen Germany"},{"name":"Centre for Integrative Neuroscience (CIN)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Beyme","sequence":"additional","affiliation":[{"name":"Section Computational Sensomotorics Hertie Institute for Clinical Brain Research  T\u00fcbingen Germany"},{"name":"Division Translational Genomics of Neurodegenerative Diseases, Hertie\u2010Institute for Clinical Brain Research and Center for Neurology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"John","sequence":"additional","affiliation":[{"name":"Section Computational Sensomotorics Hertie Institute for Clinical Brain Research  T\u00fcbingen Germany"},{"name":"Division Translational Genomics of Neurodegenerative Diseases, Hertie\u2010Institute for Clinical Brain Research and Center for Neurology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Harmuth","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics and Applied Genomics, University Hospital T\u00fcbingen University of T\u00fcbingen  T\u00fcbingen 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