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The GGC repeat expansion in <jats:italic>ZFHX3<\/jats:italic>, responsible for spinocerebellar ataxia type 4 (SCA4), has only been described in individuals of Northern Europeandescent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Uncover the genetic etiology of suspected hereditary movement disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed Oxford Nanopore long\u2010read genome sequencing on 15 individuals with suspected hereditary movement disorders. Using variant calling and ancestry inference tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified <jats:italic>ZFHX3<\/jats:italic> GGC expansions (47\u201355 repeats) in 4 patients with progressive ataxia, polyneuropathy, and vermis atrophy. One presented with rapidly progressive parkinsonism\u2013ataxia, expanding the known phenotype. Longer expansions correlated with earlier onset and severity. All carriers shared single nucleotide variants (SNVs) associated with the Swedish founder haplotype, and methylation analysis confirmed allele\u2010specific hypermethylation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These represent the first SCA4 cases identified outside Northern Europe. Our findings highlight the value of long\u2010read sequencing in resolving undiagnosed movement disorders. Published 2025. This article is a U.S. Government work and is in the public domain in the USA. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30242","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:44:23Z","timestamp":1748936663000},"page":"1433-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of <scp>GGC<\/scp> Repeat Expansions in <scp><i>ZFHX3<\/i><\/scp> among Chilean Movement Disorder Patients"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8056-365X","authenticated-orcid":false,"given":"Paula","family":"Saffie\u2010Awad","sequence":"first","affiliation":[{"name":"Cl\u00ednica Santa Mar\u00eda  Santiago 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