{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:11:46Z","timestamp":1790878306256,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1176607"],"award-info":[{"award-number":["1176607"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R28AA012725"],"award-info":[{"award-number":["R28AA012725"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple system atrophy (MSA) is a neurodegenerative disease pathologically characterized by the presence of glial cytoplasmic inclusions (GCI) composed of \u03b1\u2010synuclein aggregates. In Parkinson's disease, increases in monounsaturated fatty acids (MUFA) in phospholipid membranes promote \u03b1\u2010synuclein binding, aggregation, and toxicity, and the inhibition of stearoyl\u2010CoA desaturase (SCD), the enzyme responsible for synthesizing MUFA, alleviates \u03b1\u2010synuclein toxicity. However, little is known about phospholipid MUFA or SCD in the context of MSA pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether phospholipid MUFA and SCD levels are altered in MSA brain and related to \u03b1\u2010synuclein pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Phospholipid MUFA levels in the disease\u2010affected motor cortex white matter (MWM) and disease\u2010unaffected superior occipital cortex (SOC) of postmortem MSA and control brain were analyzed using liquid chromatography\u2013mass spectrometry. Brain GCI, \u03b1\u2010synuclein, and SCD were analyzed using immunofluorescence, Western blotting, and quantitative polymerase chain reaction (qPCR). Serum SCD was analyzed using ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MUFA in phosphatidic acid, phosphatidylcholine, and phosphatidylethanolamine were elevated in MSA MWM compared with control MWM by 3.9%, 8.8%, and 9.5%, respectively, whereas none were altered in SOC. MUFA were strongly associated with \u03b1\u2010synuclein only in MWM. SCD mRNA and protein expression were decreased only in MSA MWM compared with control MWM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest a prevalence of MUFA dysregulation in specific regions of MSA brain, resulting in MUFA levels remaining high despite decreases in SCD expression. Our study has provided new insights into an unrecognized pathway in MSA and opened a new area of research for better understanding MSA pathogenesis. \u00a9 2025 The Author(s). <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30248","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:25:34Z","timestamp":1747981534000},"page":"1940-1950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dysregulation of Monounsaturated Fatty Acids is Related to \u03b1\u2010Synuclein in Multiple System Atrophy"],"prefix":"10.1002","volume":"40","author":[{"given":"Finula I.","family":"Isik","sequence":"first","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney NSW Australia"},{"name":"School of Medical Sciences The University of 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