{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:45:59Z","timestamp":1791434759440,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2145 SyNergy"],"award-info":[{"award-number":["EXC 2145 SyNergy"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ID 390857198"],"award-info":[{"award-number":["ID 390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Progressive supranuclear palsy (PSP) is a neurodegenerative disease driven by 4\u2010repeat \u03c4 pathology, which is thought to propagate across interconnected neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We hypothesized that interconnected brain regions exhibit correlated atrophy, and that atrophy propagates network\u2010like from fast\u2010declining epicenters to connected regions in PSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We combined resting\u2010state functional magnetic resonance imaging (fMRI) connectomics with two independent 12\u2010month longitudinal structural magnetic resonance imaging (MRI) datasets of PSP\u2010Richardson syndrome (PSP\u2010RS) patients (\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>discovery<\/jats:sub>\n                      \/\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>validation<\/jats:sub>\n                      \u2009=\u2009114\/90). MRI\u2010based gray matter volumes were assessed for 246 regions of the Brainnetome atlas and converted to w\u2010scores indicating local atrophy (ie, volumes adjusted for age, sex, and intracranial volume based on regression models determined in a sample of 377 healthy amyloid\u2010 and \u03c4\u2010negative controls from the Alzheimer's Disease Neuroimaging Initiative [ADNI]). Annual volume changes were determined for each Brainnetome region of interest using longitudinal structural MRI. Resting\u2010state fMRI from 69 ADNI healthy controls was used to determine a connectivity template.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed pronounced atrophy and volume decline in the frontal lobe and subcortical regions bilaterally. Correlated atrophy and volume changes were found among interconnected brain regions, with regions with severe atrophy or rapid decline being strongly connected to similarly affected areas, whereas minimally affected regions were connected to less affected areas. Connectivity patterns of atrophy epicenters predicted patient level atrophy and volume decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings show that key subcortical and frontal brain regions undergo atrophy in PSP\u2010RS and that gray matter atrophy expands across interconnected brain regions, supporting the view that neurodegeneration patterns may follow the trans\u2010neuronal \u03c4 propagation pattern in PSP\u2010RS. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30257","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:02:22Z","timestamp":1749726142000},"page":"2102-2115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-8145","authenticated-orcid":false,"given":"Carla","family":"Palleis","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) \u2010 Site Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-2083","authenticated-orcid":false,"given":"Andrea","family":"Quattrone","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t  Munich Germany"},{"name":"Neuroscience Research Centre Magna Graecia University  Catanzaro Italy"},{"name":"Institute of Neurology, Department of Medical and Surgical Sciences Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7116-9741","authenticated-orcid":false,"given":"Amir","family":"Dehsarvi","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD) University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian N.","family":"Roemer\u2010Cassiano","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t  Munich Germany"},{"name":"Institute for Stroke and Dementia Research (ISD) University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t  Munich Germany"},{"name":"Max Planck School of Cognition  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2572-5062","authenticated-orcid":false,"given":"Alexander M.","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital, Ludwig\u2010Maximilians\u2010Universit\u00e4t  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The AL\u2010108\u2010231 Investigators, the PASSPORT Study 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