{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:44:39Z","timestamp":1787237079094,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several neurodegenerative diseases can mimic the clinical presentation of progressive supranuclear palsy (PSP), limiting accurate diagnosis during life. This has important implications for clinical practice, biomarker studies, and therapeutic trial design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate whether the proportion of clinically diagnosed PSP patients with non\u2010PSP pathology (termed \u2018mimics\u2019) has changed over the past 20\u2009years since last examined in this cohort, and to identify clinical features that distinguish confirmed PSP from these mimics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed the clinical records of pathologically confirmed PSP patients donated to the Queen Square Brain Bank from 2010 to 2022, and PSP mimics donated from 1989 to 2022. Demographic information, clinical features, and progression milestones were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 236 pathologically confirmed PSP patients and 72 mimics. The main pathologies in PSP mimics were Lewy body disease (30.5%), corticobasal degeneration (23.6%), and multiple system atrophy (18.1%). A final clinical diagnosis of PSP between 2010 and 2022 had a positive predictive value of 86% for underlying PSP pathology and a false negative rate of 17%. Clinical features present in the first 3\u2009years that favoured non\u2010PSP pathology in this cohort include levodopa responsiveness, orthostatic hypotension, dysarthria, and a subcortical phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinical diagnosis of PSP has improved since last examined in this cohort 20\u2009years ago. Although certain clinical features may point to non\u2010PSP pathologies, a proportion of patients are difficult to distinguish on clinical grounds alone. This should be reflected in clinical trial design, and further studies will be required to determine the utility of emerging biomarkers in this setting. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30261","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:10:23Z","timestamp":1749723023000},"page":"2116-2128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical Diagnosis of Progressive Supranuclear Palsy (PSP): A Clinicopathological Comparison of Patients with Confirmed PSP and Clinical Mimics"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9274-6409","authenticated-orcid":false,"given":"Sarah","family":"Wrigley","sequence":"first","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology, University College London  London United Kingdom"},{"name":"Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Reta Lila Weston Institute of Neurological Studies UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-2680","authenticated-orcid":false,"given":"Patrick W.","family":"Cullinane","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology, University College London  London United Kingdom"},{"name":"Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Reta Lila Weston Institute of Neurological Studies UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"Queen Square Movement Disorders Centre UCL Queen Square Institute of 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Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8425-5186","authenticated-orcid":false,"given":"Mar\u00eda","family":"Rivera\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3277-7813","authenticated-orcid":false,"given":"Toby","family":"Curless","sequence":"additional","affiliation":[{"name":"Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leckhna Paras","family":"Chajed","sequence":"additional","affiliation":[{"name":"Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology  London United 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