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Cases were classified as Lewy body disease (LBD)\u2010present (n\u2009=\u200913) if they had Lewy\u2010related pathology and LBD\u2010absent (n\u2009=\u200941) if they did not have Lewy\u2010related pathology. QSM was calculated for the whole SN and the two subregions: pars compacta (SNc) and pars reticulata (SNr). Nonparametric Wilcoxon rank\u2010sum tests were used to compare SN QSM values between LBD\u2010present and LBD\u2010absent cases. Area under the receiver operating characteristic (ROC) curve (AUC) analyses tested the accuracy of SN QSM values to distinguish the two groups. Associations of QSM values in the SN and its subregions with clinical features were tested with Spearman's correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The LBD\u2010present group had higher QSM values in the SNc (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008) than the LBD\u2010absent group with no differences in SNr. QSM values of the SNc distinguished LBD\u2010present and LBD\u2010absent cases with good accuracy (AUC\u2009=\u20090.74) and correlated with the presence of parkinsonism and parkinsonism severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study provides neuropathological confirmation of the utility of SNc QSM as an in vivo biomarker of Lewy\u2010related pathology. Imaging evidence of abnormal iron deposition in the SNc could potentially serve as a biomarker for inclusion in emerging research frameworks aimed at defining individuals with LBD based on their biological characteristics. Ultimately, this could facilitate more precise diagnoses and guide treatment strategies in LBD. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30265","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:44:03Z","timestamp":1750650243000},"page":"2129-2138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Substantia Nigra Iron Deposition in Lewy Body Disease: A Magnetic Resonance Imaging and Neuropathology 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