{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:39Z","timestamp":1772118819407,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00003\/2"],"award-info":[{"award-number":["MC_UU_00003\/2"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R020418\/1"],"award-info":[{"award-number":["MR\/R020418\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/X023141\/1"],"award-info":[{"award-number":["MR\/X023141\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000627","name":"Guarantors of Brain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tremor phase\u2010locked deep brain stimulation (DBS) has been shown to modulate symptom severity in postural tremor, including essential and dystonic tremor, with less energy than existing systems. Previous studies focused on unilateral stimulation; it remains unknown how tremor asymmetry interacts with stimulation in the context of bilateral phase\u2010locked DBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Archival limb acceleration from nine essential tremor patients was analyzed for asymmetries in tremor amplitude, frequency, and instability, and their relationship with continuous high\u2010frequency DBS (cDBS). Bilateral phase\u2010locked DBS was tested in one essential tremor and one dystonic tremor patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postural tremor is asymmetric, with larger tremor power linked to smaller amplitude and frequency instability in one hand. These asymmetries were significantly reduced during cDBS, with greater effects on larger amplitude tremors. Bilateral phasic DBS effects were also asymmetric.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study enhances understanding of tremor asymmetry and its relationship with DBS, offering insights for patient\u2010specific tremor treatments. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30275","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T05:05:29Z","timestamp":1750655129000},"page":"1977-1982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tremor Asymmetry and the Development of Bilateral Phase\u2010Specific Deep Brain Stimulation for Postural Tremor"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-1902","authenticated-orcid":false,"given":"Shenghong","family":"He","sequence":"first","affiliation":[{"name":"Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alceste","family":"Deli","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy O.","family":"West","sequence":"additional","affiliation":[{"name":"Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"},{"name":"Department of Bioengineering Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando R.","family":"Plazas","sequence":"additional","affiliation":[{"name":"Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alek","family":"Pogosyan","sequence":"additional","affiliation":[{"name":"Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Wiest","sequence":"additional","affiliation":[{"name":"Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Wehmeyer","sequence":"additional","affiliation":[{"name":"Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"},{"name":"Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, and Faculty of Medicine University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahd","family":"Baig","sequence":"additional","affiliation":[{"name":"Neurosciences Research Centre, Molecular and Clinical Sciences Institute, City St. George's University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-3639","authenticated-orcid":false,"given":"Francesca","family":"Morgante","sequence":"additional","affiliation":[{"name":"Neurosciences Research Centre, Molecular and Clinical Sciences Institute, City St. George's University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, and Faculty of Medicine University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Hart","sequence":"additional","affiliation":[{"name":"Neurosciences Research Centre, Molecular and Clinical Sciences Institute, City St. George's University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"FitzGerald","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford  Oxford UK"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerle","family":"Visser\u2010Vandewalle","sequence":"additional","affiliation":[{"name":"Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, and Faculty of Medicine University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erlick A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Neurosciences Research Centre, Molecular and Clinical Sciences Institute, City St. George's University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander L.","family":"Green","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences University of Oxford  Oxford UK"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford 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