{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:08:39Z","timestamp":1792066119166,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy of pallidothalamic tract (PTT)\u2010focused ultrasound (FUS) in the treatment of advanced Parkinson's disease (aPD) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the safety and efficacy of PTT\u2010FUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine patients with aPD underwent PTT\u2010FUS. Clinical assessments, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS), were conducted at baseline and 3\u2009months after the first procedure, with contralateral procedure and clinical evaluation up to 12\u2009months later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MDS\u2010UPDRS Part III <jats:italic>on<\/jats:italic>\/<jats:italic>off<\/jats:italic> medication scores improved from 26.1\u2009\u00b1\u200915.4\/54.4\u2009\u00b1\u200916.7 at baseline to 11.9\u2009\u00b1\u20099.6\/26.6\u2009\u00b1\u200915.9 at 3\u2009months after the unilateral procedure. The Unified Dyskinesia Rating Scale score improved from 25.0\u2009\u00b1\u200918.9 to 3.6\u2009\u00b1\u20097.0. Because of ipsilateral and axial symptom improvement, treatment was terminated after the unilateral procedure in seven patients. Adverse events included permanent freezing in one patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unilateral PTT\u2010FUS improves wearing off and dyskinesia, with bilateral effects observed short term. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.30281","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T09:37:27Z","timestamp":1752745047000},"page":"1983-1989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bilateral Effects of Unilateral Pallidothalamic Tractotomy Using Focused Ultrasound in Parkinson's Disease"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2424-2218","authenticated-orcid":false,"given":"Jun","family":"Ikezawa","sequence":"first","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Neurological Hospital  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