{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:06:10Z","timestamp":1790888770951,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS089619\u201001A1"],"award-info":[{"award-number":["R01 NS089619\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The long prodromal phase of Parkinson's disease (PD) and the link the disease has with metabolic factors suggest that metabolomics could help identify affected individuals at early stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal was to examine whether plasma metabolomic profiles could identify individuals in the prodromal and clinical phase of PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We quantified and compared the plasma metabolomic profiles of 922 individuals with PD who provided blood samples at a median of 11\u2009years before (n\u2009=\u2009809) or 2\u2009years after (n\u2009=\u2009113) disease diagnosis to that of matched controls, all selected from three established cohort studies (Nurses' Health Study, Health Professionals Follow\u2010up Study, and Cancer Prevention Study II). We used conditional logistic regression models and machine learning techniques to identify metabolites predicting prodromal and clinically manifest PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Several metabolites, especially amino acids, acyl\u2010carnitines, and other lipids were nominally associated with PD since the years leading to disease diagnosis. Metabolites proposed as biomarkers of foods or care products tended to be associated with a higher PD risk closer to disease diagnosis. Metabolites reflecting higher intake of coffee, smoking, and acetaminophen tended to be associated with a lower PD risk over the course of the disease. Metabolomic profiles in prodromal samples were unable to accurately predict future clinical PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Metabolic pathways related to the metabolism of amino acids and lipids may be involved in PD progression. Metabolomic differences may also result from behavioral changes and medical management, emphasizing the need to consider prodromal and clinical data in future studies. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30308","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:15:41Z","timestamp":1755076541000},"page":"2209-2219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma Metabolomics Profiles in Prodromal and Clinical Parkinson's Disease"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9791-3196","authenticated-orcid":false,"given":"Mario H.","family":"Flores\u2010Torres","sequence":"first","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0441-6268","authenticated-orcid":false,"given":"Xiaojing","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Jeanfavre","sequence":"additional","affiliation":[{"name":"Metabolomics Platform Broad Institute of Massachusetts Institute of Technology and Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clary","family":"Clish","sequence":"additional","affiliation":[{"name":"Metabolomics Platform Broad Institute of Massachusetts Institute of Technology and Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Population Science American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie L.","family":"McCullough","sequence":"additional","affiliation":[{"name":"Department of Population Science American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Healy","sequence":"additional","affiliation":[{"name":"Brigham Multiple Sclerosis Center Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-8280","authenticated-orcid":false,"given":"Michael A.","family":"Schwarzschild","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-6986","authenticated-orcid":false,"given":"Kjetil","family":"Bjornevik","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. 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