{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:37:59Z","timestamp":1784219879312,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FORT23\/00034"],"award-info":[{"award-number":["FORT23\/00034"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00248"],"award-info":[{"award-number":["PI21\/00248"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI24\/01083"],"award-info":[{"award-number":["PI24\/01083"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2022 FI_B 00996"],"award-info":[{"award-number":["2022 FI_B 00996"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"'la Caixa' Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","award":["PR(AMI)481\/2021"],"award-info":[{"award-number":["PR(AMI)481\/2021"]}],"id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Deep brain stimulation of the globus pallidus internus (DBS\u2010GPi) has shown efficacy in adult patients with\n                      <jats:italic>SGCE<\/jats:italic>\n                      \u2010related myoclonus dystonia. However, evidence regarding its impact in pediatric populations is limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim was to evaluate motor and non\u2010motor outcomes following DBS\u2010GPi intervention in children and adolescents with\n                      <jats:italic>SGCE<\/jats:italic>\n                      \u2010MD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten patients (mean age 12.8\u2009\u00b1\u20093.4\u2009years) underwent DBS\u2010GPi. Blinded experts rated patients with the Unified Myoclonus, Burke\u2010Fahn\u2010Marsden, Writer's cramp and Gait Dystonia rating scales. Psychiatric and quality\u2010of\u2010life outcomes were evaluated using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria and Quality of Life in Neurological Disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant improvements were observed in myoclonus (68.1%), generalized dystonia (63.2%), and dystonia during writing (48.1%), walking (70.3%) and running (44.2%) after 3.8\u2009\u00b1\u20092.4\u2009years of the surgery. Psychiatric symptoms remained stable, while quality\u2010of\u2010life assessments revealed reductions in anxiety, fatigue, and stigma (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      DBS\u2010GPi in children with\n                      <jats:italic>SGCE<\/jats:italic>\n                      \u2010myoclonus dystonia mitigates long\u2010term disability, potentially enhancing academic, social, and professional prospects. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30309","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:44:23Z","timestamp":1754109863000},"page":"2234-2242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Deep Brain Stimulation in Children and Adolescents with \u03b5\u2010Sarcoglycan Myoclonus Dystonia Causes a Sustained Improvement in Motor Functionality and Quality of Life"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-2687","authenticated-orcid":false,"given":"Ainara","family":"Salazar\u2010Villacorta","sequence":"first","affiliation":[{"name":"Hospital Universitari Vall d'Hebr\u00f3n  Barcelona Spain"},{"name":"University College London, Institute of Neurology  London United 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