{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:07:04Z","timestamp":1789816024365,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Increasing evidence suggests significant associations between Parkinson's disease (\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      ) and cancer risks, with epidemiological studies revealing a complex relationship.\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      patients exhibit lower risks of lung, genitourinary, and gastrointestinal cancers but higher risks of melanoma and brain cancers. Despite these observations, the underlying mechanisms between\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      and cancers are poorly understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to identify molecular signatures underlying this complex connection by assessing transcriptional associations between PD\u2010related genes, patient survival, and the cancer\u2010specific co\u2010expression networks in which these genes are involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To explore this, we analyzed transcriptomic data from 18 cancer types in the TCGA dataset (n\u2009=\u20096088) and 16 cancer types in the DepMap dataset (n\u2009=\u2009682). We focused on seven genes causally implicated in PD (\n                      <jats:italic>SNCA<\/jats:italic>\n                      ,\n                      <jats:italic>PINK1<\/jats:italic>\n                      ,\n                      <jats:italic>LRRK2<\/jats:italic>\n                      ,\n                      <jats:italic>PRKN\/PARK2<\/jats:italic>\n                      ,\n                      <jats:italic>PARK7<\/jats:italic>\n                      ,\n                      <jats:italic>GBA1<\/jats:italic>\n                      , and\n                      <jats:italic>ATP13A2<\/jats:italic>\n                      ) and conducted in silico analyses, to evaluate their associations with survival and correlation with genes, pathways, and response to drugs in the context of cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our findings revealed that the expression levels of the genes correlated with overall survival in a cancer\u2010specific manner, often influenced by the TP53 genetic status. These genes were also associated with key cancer hallmarks such as genomic instability and cell proliferation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that PD and cancer may be connected through shared biological pathways, some overlapping with cancer hallmarks, and highlights the need for future mechanistic and functional studies to clarify the role of PD genes in cancer biology. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.30321","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T05:55:50Z","timestamp":1755064550000},"page":"2419-2430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic and Biological Roles of Parkinson's Disease\u2010Associated 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