{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:36:06Z","timestamp":1792636566279,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01NS114001"],"award-info":[{"award-number":["U01NS114001"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Light therapy (LT) in Parkinson's disease improves sleep. Specific LT parameters require further study, including optimal frequency.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n We aimed to determine if once\u2010 or twice\u2010daily bright white light therapy (BWLT) improves sleep. Secondary aims compared once\u2010weekly BWLT to twice\u2010daily dim red light therapy (DRLT) as controls, estimated effects on fatigue, and adherence.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A 16\u2010week, randomized, phase 2, sham\u2010controlled, dose\u2010selection trial to select the superior BWLT frequency based on change in Parkinson's Disease Sleep Scale\u20102 (PDSS\u20102), participant burden, and safety. Participants were randomized to 8\u2009weeks of twice\u2010daily BWLT, once\u2010daily BWLT, once\u2010weekly BWLT, or twice\u2010daily DRLT. An improvement of \u22651.7 points in 8\u2010week change of PDSS\u20102 by daily BWLT relative to either control warranted advancing to a phase 3 trial.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 150 participants were randomized (mean [SD], 67 [8.6] years; 57 [38%] female; PDSS\u20102 17.1 [6.7]). Mean 8\u2010week change from baseline in PDSS\u20102 score improved (twice\u2010daily BWLT \u22122.6 [95% CI: \u22124.4, \u22120.7]; once\u2010daily BWLT \u20101.5 [\u22123.3, 0.3]; once\u2010weekly BWLT \u22120.4 [\u22122.2, 1.4]; twice\u2010daily DRLT \u22121.8 [\u22123.6, 0.1]) but did not meet criteria for advancing. Mean 8\u2010week change from baseline in Parkinson's Disease Fatigue Scale (PFS\u201016) score improved (twice\u2010daily BWLT \u22126.4 [\u22129.8, \u22123.0]; once\u2010daily BWLT \u22122.2 [\u22125.5, 1.1]; once\u2010weekly BWLT \u22120.5 [\u22123.9, 2.8]; and twice\u2010daily DRLT \u22123.8 [\u22127.3, \u22120.4]). Mean adherence to LT was 63%\u201386%.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n ENLITE\u2010PD did not meet the criteria for advancing daily LT to a phase 3 trial. LT was safe and well\u2010tolerated with good adherence. Once\u2010weekly BWLT was a non\u2010inferior control compared with twice\u2010daily DRLT. \u00a9 2025 International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.70009","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T09:10:35Z","timestamp":1757149835000},"page":"2445-2456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["ENLITE PD:<\/scp>\n A Randomized Clinical Trial of Light Therapy for Impaired Sleep in Parkinson's Disease"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9237-1516","authenticated-orcid":false,"given":"Aleksandar","family":"Videnovic","sequence":"first","affiliation":[{"name":"Department of Neurology Mass General Brigham Boston Massachusetts USA"},{"name":"Neurological Clinical Research Institute Massachusetts General Hospital Boston Massachusetts 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