{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:01:03Z","timestamp":1764331263716,"version":"3.46.0"},"reference-count":65,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013116","name":"Merz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201016\u2010CE37\u20100003\u201003"],"award-info":[{"award-number":["ANR\u201016\u2010CE37\u20100003\u201003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P400PM_183958","P5R5PM_203160\/1"],"award-info":[{"award-number":["P400PM_183958","P5R5PM_203160\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018659","name":"Amadys","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cervical dystonia is characterized by abnormal neck and head movements, possibly related to a dysfunction of the interstitial nucleus of Cajal (INC) and the head neural integrator, a system responsible for the control of head and eye movements. However, neuroanatomical evidence of alterations in the head neural integrator in cervical dystonia is sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We investigated structural and functional integrity of the INC and its connections in cervical dystonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional, observational study compared 19 cervical dystonia patients and 21 healthy controls, using anatomical, diffusion\u2010weighted, and resting\u2010state functional images. We reconstructed tracts converging on the INC, and involved in the control of head movements. We evaluated group differences in microstructural integrity using fixel\u2010based analysis, and effective connectivity using dynamic causal modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with controls, patients showed microstructural abnormalities within the INC and cerebral peduncle. Effective connectivity showed abnormal self\u2010inhibition in the INC, substantia nigra, and vermis in patients, with decreased excitation from the substantia nigra to the INC, increased inhibition from the deep cerebellar nuclei and primary sensorimotor cortex, and decreased excitation from the INC to the cerebellar vermis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A dysfunction of the INC might contribute to altered sensorimotor integration in cervical dystonia, and abnormal feedback from its afferent connections could alter its integrative function, resulting in a disturbed head and neck posture. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    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