{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:25:36Z","timestamp":1783445136480,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["#399711"],"award-info":[{"award-number":["#399711"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Plasma biomarkers of neurodegeneration, astrogliosis, and neuroinflammation have been studied as potential biomarkers in neurodegenerative diseases. This study investigated whether these markers may predict phenoconversion to Parkinson's disease or dementia with Lewy bodies (DLB) in idiopathic\/isolated REM sleep behavior disorder (iRBD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this longitudinal, single\u2010center, iRBD cohort study (enrolled 2004\u20132022), plasma glial fibrillary acidic protein (GFAP), interleukin\u20106 (IL\u20106), neurofilament light chain (NfL), snare\u2010associated protein 25 (SNAP25), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), and chitinase 3\u2010like protein (YKL\u201040) were measured using NeuroToolKit (Roche Diagnostics International Ltd). Associations between baseline plasma biomarkers and eventual development of manifest synucleinopathy during follow\u2010up (up to 11\u2009years) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 143 iRBD participants (110 male, 67.7\u2009\u00b1\u20098.0\u2009years) were included. Compared with non\u2010phenoconverters, DLB\u2010converters had higher baseline GFAP (0.115 vs. 0.071\u2009ng\/ml,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002) and NfL (3.55 vs. 2.51\u2009pg\/ml,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.010). Baseline levels predicted DLB using non\u2010phenoconverters without mild cognitive impairment as reference with area under the curve (AUC)\u2009=\u20090.79 for GFAP and 0.84 for NfL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Higher plasma GFAP and NfL were associated with increased risk of developing DLB in prodromal synucleinopathies. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70016","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T09:07:24Z","timestamp":1755767244000},"page":"2497-2503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic\/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8497-2314","authenticated-orcid":false,"given":"Aline","family":"Delva","sequence":"first","affiliation":[{"name":"The Neuro (Montreal Neurological Institute\u2010Hospital) McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Zatti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Neurology Unit University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research in Sleep Medicine H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Research Institute of McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Montplaisir","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research in Sleep Medicine H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research in Sleep Medicine H\u00f4pital du Sacr\u00e9\u2010Coeur de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Department of Psychology Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendlyn","family":"Kollmorgen","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH  Penzberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Kam\u2010Thong","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel F. 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