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The recently identified somato\u2010cognitive action network (SCAN) has been implicated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We tested whether the effector\u2010agnostic SCAN may constitute a central pathology shared across dystonia subtypes, whereas the effector\u2010specific regions in the primary sensorimotor cortex may show distinct functional changes specific to the dystonic body part.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected functional magnetic resonance imaging (MRI) from patients with focal dystonia (laryngeal dystonia [LD], N\u2009=\u200924; focal hand dystonia [FHD], N\u2009=\u200918) and healthy control participants (N\u2009=\u200921). Regions of interest were selected a priori within the basal ganglia\u2010thalamo\u2010cortical and cerebello\u2010thalamo\u2010cortical sensorimotor pathways. We investigated dystonia\u2010dependent resting\u2010state connectivity changes: between SCAN and related cortical regions, between cortical and noncortical regions, and among noncortical regions. Cortical network boundaries were individualized based on resting\u2010state data. Separately, individualized hand and mouth\/larynx regions were also generated from task\u2010based MRI (finger\u2010tapping and phonation, respectively) for comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both focal dystonia subtypes showed significant functional changes (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.048 for LD,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017 for FHD) compared to controls, driven by SCAN's higher functional connectivity to task\u2010based mouth\/larynx region and concomitantly lower connectivity to the cingulo\u2010opercular network. No significant subcortical or cerebellar changes were observed when LD and FHD were modeled as independent groups. However, exploratory analysis combining LD and FHD suggested a dystonia\u2010dependent asynchronization between SCAN and sensorimotor cerebellum (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.010) that may indicate a pathological rather than compensatory process.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We demonstrate that SCAN is uniquely associated with focal dystonia dysfunction beyond the dystonic effector regions, offering insights into pathophysiology and treatments. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70021","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:21:14Z","timestamp":1756380074000},"page":"2331-2343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Somato\u2010Cognitive Action Network in Focal Dystonia"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-3006","authenticated-orcid":false,"given":"Yuchao","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Cognitive Neuroscience Duke University  Durham North Carolina USA"},{"name":"Department of Physical Therapy MGH Institute of Health Professions  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-3402","authenticated-orcid":false,"given":"Baothy","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Science MGH Institute of Health Professions  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxun","family":"Ren","sequence":"additional","affiliation":[{"name":"Changping Laboratory  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Chen","sequence":"additional","affiliation":[{"name":"Neurosciences Research Program, Gillette Children's Specialty Healthcare  St Paul Minnesota USA"},{"name":"Non\u2010invasive Neuromodulation Laboratory University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Changping Laboratory  Beijing China"},{"name":"Academy for Advanced Interdisciplinary Studies Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Research Imaging Center University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Li","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Radiology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Changping Laboratory  Beijing China"},{"name":"Academy for Advanced Interdisciplinary Studies Peking University  Beijing China"},{"name":"Biomedical Pioneering Innovation Center Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6397-4054","authenticated-orcid":false,"given":"Teresa J.","family":"Kimberley","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy MGH Institute of Health Professions  Boston Massachusetts USA"},{"name":"Department of Rehabilitation Science MGH Institute of Health Professions  Boston Massachusetts USA"},{"name":"Athinoula A. 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