{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:07:05Z","timestamp":1792624025030,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF\u2010009634"],"award-info":[{"award-number":["MJFF\u2010009634"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. 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Allogeneic human mesenchymal stem cells (allo\u2010hMSCs) may reduce neuroinflammation and improve motor symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy of repeated intravenous doses of 10\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \/kg allo\u2010hMSCs in improving motor symptoms in patients with PD (PwP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this phase 2, randomized, placebo\u2010controlled trial (November 2020\u2013July 2023), mild\u2010to\u2010moderate PwP received either three allo\u2010hMSC infusions, one placebo followed by two allo\u2010hMSC infusions, or three placebo infusions at 18\u2010week intervals. Follow\u2010up lasted 88\u2009weeks. The primary outcome was a &gt;70% posterior probability (PP) of a difference in the proportion of participants with \u22655\u2010point improvement in OFF\u2010medication Movement Disorder Society Sponsored Revision of the Unified Parkinson's Disease Rating Scale\u2010Part III (MDS\u2010UPDRS\u2010III) at week 62. Bayesian analysis was conducted using R v4.2.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010five PwP were enrolled. A larger proportion of subjects achieved a \u22655\u2010point improvement in MDS\u2010UPDRS\u2010III in the three\u2010infusion arm compared with placebo at week 62 (mean difference [MD]: 5.0%, PP\u2009=\u200993.7%), translating to a 16.9\u2010point improvement in MDS\u2010UPDRS\u2010III in the three\u2010infusion arm compared with a 14.6\u2010point improvement in the placebo arm. Conversely, fewer subjects in the two\u2010infusion arm compared with placebo showed \u22655\u2010point improvement at week 62 (MD: \u201362.4%, PP \u2265\u200999.9%), translating to only a 3.9\u2010point improvement in MDS\u2010UPDRS\u2010III in the two\u2010infusion arm. However, improvement in MDS\u2010UPDRS\u2010III was seen across all treatment arms. Adverse events were mild and transient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Three infusions of 10\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      allo\u2010hMSCs\/kg improved motor function in mild\u2010to\u2010moderate PwP, while two infusions showed less improvement than placebo. To address this discrepancy, future studies should conduct functional potency assays to understand batch\u2010to\u2010batch variability affecting clinical efficacy. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70028","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T06:30:26Z","timestamp":1756794626000},"page":"2688-2699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Allogeneic Bone Marrow\u2010Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9348-2587","authenticated-orcid":false,"given":"Mya 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Department of Neurology McGovern Medical School at UTHealth Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7371-8680","authenticated-orcid":false,"given":"Emily","family":"Tharp","sequence":"additional","affiliation":[{"name":"Movement Disorders Division, Department of Neurology McGovern Medical School at UTHealth Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikunj B.","family":"Satani","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Cerebrovascular Diseases McGovern Medical School at UTHealth Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3378-7669","authenticated-orcid":false,"given":"Jerome G.","family":"Saltarrelli","sequence":"additional","affiliation":[{"name":"Immunology &amp; Organ Transplantation Division, Department of Surgery McGovern Medical School at 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