{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:38:52Z","timestamp":1789835932179,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/0490(16118)\/2022\u2010EMR\u2010I"],"award-info":[{"award-number":["09\/0490(16118)\/2022\u2010EMR\u2010I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI22\/00226"],"award-info":[{"award-number":["FI22\/00226"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson's","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The catechol\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010methyltransferase (\n                      <jats:italic>COMT<\/jats:italic>\n                      ) gene is involved in brain catecholamine metabolism, but its association with Parkinson's disease (PD) risk remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Our aim was to investigate the relationship between\n                      <jats:italic>COMT<\/jats:italic>\n                      genetic variants and PD risk across diverse ancestries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed\n                      <jats:italic>COMT<\/jats:italic>\n                      variants in 2251 PD patients and 2835 controls of European descent using whole\u2010genome sequencing from the Accelerating Medicines Partnership\u2010Parkinson Disease (AMP\u2010PD), along with 20,427 PD patients and 11,837 controls from 10 ancestries using genotyping data from the Global Parkinson's Genetics Program (GP2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using the largest case\u2013control datasets to date, no significant enrichment of\n                      <jats:italic>COMT<\/jats:italic>\n                      risk alleles in PD patients was observed across any ancestry group after correcting for multiple testing. Among Europeans, no correlations with cognitive decline, motor function, motor complications, or time to levodopa\u2010induced dyskinesia onset were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study highlights the need for increased representation of diverse ancestries to better understand the role of\n                      <jats:italic>COMT<\/jats:italic>\n                      variants in PD. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70040","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T06:55:20Z","timestamp":1758696920000},"page":"2819-2824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does\n                    <scp>\n                      <i>COMT<\/i>\n                    <\/scp>\n                    Play a Role in Parkinson's Disease Susceptibility across Diverse Ancestral Populations?"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8221-3816","authenticated-orcid":false,"given":"Miguel","family":"Mart\u00edn\u2010B\u00f3rnez","sequence":"first","affiliation":[{"name":"Unidad de Trastornos del Movimiento, Servicio de Neurolog\u00eda, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Seville Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisar","family":"Shar","sequence":"additional","affiliation":[{"name":"Department of clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United Kingdom"},{"name":"NED University of Engineering and Technology  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ahmed","family":"Nour","sequence":"additional","affiliation":[{"name":"UCL Queen Square Institute of Neurology, Faculty of Brain Sciences  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London United 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