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The clinical impact of these pathologies remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To subclassify CBS patients in vivo using biomarkers for amyloid\u2010\u03b2 (A\u03b2), Tau, and \u03b1\u2010synuclein (\u03b1Syn), and assess the clinical relevance of this stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a prospective cohort study of 50 CBS patients at LMU University Hospital Munich. Biomarker analysis included cerebrospinal fluid (CSF) A\u03b242 and A\u03b242\/40, [\n                      <jats:sup>18<\/jats:sup>\n                      F]flutemetamol A\u03b2\u2010PET, [\n                      <jats:sup>18<\/jats:sup>\n                      F]PI\u20102620 tau\u2010PET, and \u03b1Syn seed amplification assays in CSF. CSF neurofilament light chain (NfL) served as a marker of neurodegeneration. Patients were stratified into six groups based on biomarker positivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tau positivity was found in 90% of CBS cases, A\u03b2 in 28%, and \u03b1Syn in 24%. Stratification identified: 52% consistent with tau\u2010predominant pathology, 18% with AD, 10% with AD+LTS, 10% with tau\u2010predominant+LTS, 4% with isolated LTS, and 6% unclassified. \u03b1Syn positivity was more frequent in AD\u2010CBS (36%) than in tau\u2010predominant\u2010CBS (16%). A\u03b2\u2010positive cases showed greater cognitive impairment; Tau positivity correlated with worse motor symptoms; \u03b1Syn\u2010positive patients had milder motor symptoms, slower progression, and lower NfL levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      CBS is molecularly heterogeneous. Biomarker\u2010based classification may enhance diagnostic precision and support personalized therapeutic strategies. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70070","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:26:00Z","timestamp":1759793160000},"page":"129-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Biomarker\u2010Based Classification of Corticobasal Syndrome"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-8145","authenticated-orcid":false,"given":"Carla","family":"Palleis","sequence":"first","affiliation":[{"name":"Department of Neurology LMU University 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