{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:08:45Z","timestamp":1783836525711,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023262","name":"Jon Moulton Charity Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00003\/2"],"award-info":[{"award-number":["MC_UU_00003\/2"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P012272\/1"],"award-info":[{"award-number":["MR\/P012272\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/V00655X\/1"],"award-info":[{"award-number":["MR\/V00655X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W024810\/1"],"award-info":[{"award-number":["MR\/W024810\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203147\/Z\/16\/Z"],"award-info":[{"award-number":["203147\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The corticobasal ganglia network in Parkinson's disease (PD) is characterized by the occurrence of transient episodes of exaggerated beta frequency oscillatory synchrony, known as bursts. Although it is known that bursts of prolonged duration associate closely with motor impairments, the mechanisms leading to burst initiation remain poorly understood. Related to this, current adaptive deep brain stimulation (DBS) approaches reactively deliver stimulation following burst onset but cannot stimulate proactively to prevent bursts from occurring. The discovery of predictive biomarkers could allow for proactive stimulation, thereby offering potential for improvements in therapeutic efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to address this issue, by using deep neural networks to discover features of basal ganglia activity that reliably precede beta burst onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We developed a deep learning model to predict burst onset from subthalamic nucleus (STN) activity recordings in PD patients. Our model provides patient\u2010specific predictions in two independent datasets of STN recordings, including prolonged\u2010duration recordings from sensing\u2010enabled DBS devices during naturalistic behaviors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The occurrence of STN beta bursts can be reliably predicted up to 100\u2009ms prior to onset. Importantly, our results reveal that a dip in the beta amplitude\u2014which is likely to be indicative of a phase reset of oscillatory populations occurring between 80 and 100\u2009ms prior to burst onset\u2014is a predictive biomarker for burst occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings demonstrate proof\u2010of\u2010principle for the feasibility of beta burst prediction and inform the future development of intelligent DBS approaches with the capability of proactive stimulation to prevent beta burst occurrence. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70076","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:55:31Z","timestamp":1759485331000},"page":"2615-2627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prediction of Pathological Subthalamic Nucleus Beta Burst Occurrence in Parkinson's Disease"],"prefix":"10.1002","volume":"40","author":[{"given":"Bahman","family":"Abdi\u2010Sargezeh","sequence":"first","affiliation":[{"name":"MRC Brain Network Dynamics Unit University of Oxford  Oxford UK"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepehr","family":"Shirani","sequence":"additional","affiliation":[{"name":"Mental Health Neuroscience Department, Division of Psychiatry and Max Planck UCL Centre for Computational Psychiatry and Ageing Research University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Sharma","sequence":"additional","affiliation":[{"name":"MRC Brain Network Dynamics Unit University of Oxford  Oxford UK"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"MRC Brain Network Dynamics Unit University of Oxford  Oxford UK"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Green","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harith","family":"Akram","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-4946","authenticated-orcid":false,"given":"Ludvic","family":"Zrinzo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Limousin","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-1813","authenticated-orcid":false,"given":"Tom","family":"Foltynie","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Denison","sequence":"additional","affiliation":[{"name":"MRC Brain Network Dynamics Unit University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8038-3029","authenticated-orcid":false,"given":"Huiling","family":"Tan","sequence":"additional","affiliation":[{"name":"MRC Brain Network Dynamics Unit University of Oxford  Oxford UK"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Litvak","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Human Neuroimaging University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Neurology Surgery University of California San Francisco  San Francisco USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Starr","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of California San Francisco  San Francisco USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0152-9294","authenticated-orcid":false,"given":"Ashwini","family":"Oswal","sequence":"additional","affiliation":[{"name":"MRC Brain Network Dynamics Unit University of Oxford  Oxford UK"},{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-03-01033.2001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.217489"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000034"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26759"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww048"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04717.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.11.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.05.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58825-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.07.074"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx252"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1314-18.2018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.02.020"},{"issue":"17","key":"e_1_2_9_16_1","article-title":"Chronic adaptive DBS provides similar \u201con\u201d time with trend of improvement compared to continuous DBS in Parkinson's disease and 98% of participants chose to remain on aDBS (S2.008)","volume":"102","author":"Bronte\u2010Stewart H","year":"2024","journal-title":"Neurology"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-00897-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23951"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00229-z"},{"key":"e_1_2_9_20_1","article-title":"Adaptive vs conventional deep brain stimulation of the subthalamic nucleus for treatment of Parkinson's disease: a multicenter retrospective study","author":"Li Q","year":"2025","journal-title":"Neuromodulation"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","unstructured":"IsaiasIU MarcegliaS BorelliniL et al.Chronic adaptive versus conventional deep brain stimulation in Parkinson's disease: a blinded randomized pilot trial.medRxiv;https:\/\/doi.org\/10.1101\/2025.02.20.25322374.","DOI":"10.1101\/2025.02.20.25322374"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-313518"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25366-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004351"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29415"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad233"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.10.68"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.205542"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.9.1402"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26602"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae004"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.30163"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.08.068"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/aace8c"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X20909693"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118432"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1134599"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00772-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.113977"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.08.028"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03196-z"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2021.650050"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1156838"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200187"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28625"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2024.04.006"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102397"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009116"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.08.011"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2014.11.001"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1819975116"},{"key":"e_1_2_9_52_1","doi-asserted-by":"crossref","unstructured":"Abdi\u2010SargezehB ShiraniS SharmaA et al.Predicting long and short duration Beta bursts from subthalamic nucleus local field potential activity in Parkinson's disease. bioRxiv;2023.https:\/\/doi.org\/10.1101\/2023.09.22.558764.","DOI":"10.1101\/2023.09.22.558764"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq332"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.70076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:00:08Z","timestamp":1783836008000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.70076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/mds.70076"],"URL":"https:\/\/doi.org\/10.1002\/mds.70076","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]},"assertion":[{"value":"2025-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}