{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:23:11Z","timestamp":1789647791659,"version":"4.0.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["148\/U\/2020"],"award-info":[{"award-number":["148\/U\/2020"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Timely and accurate diagnosis of progressive supranuclear palsy (PSP) remains challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess diagnostic certainty and progression biomarkers in the PSP spectrum from \u201csuggestive of\u201d (so\u2010PSP) category as proxy of early disease, to definite (neuropathologically confirmed) cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicenter, prospective, longitudinal study of 131 participants (so\u2010PSP, n\u2009=\u200923; definite, n\u2009=\u20095) with oculometric (n\u2009=\u200947) and cerebrospinal fluid (CSF) biomarkers (n\u2009=\u200975), compared with control (n\u2009=\u200918) and Parkinson's disease (PD) subjects (n\u2009=\u200912).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anti\u2010saccade velocities were significantly reduced in so\u2010PSP versus PD and controls. CSF \u03b1\u2010synuclein seed amplification assay (asyn\u2010SAA) was positive in 20% of PSP cases (vs. 100% PD and 0% controls). Longitudinally (median of 1.3\u2009years), all probable\/possible\u2010PSP cases retained their diagnosis regardless of CSF asyn\u2010SAA result. In so\u2010PSP, worse saccades' variables and negative\/low\u2010fluorescence\u2010positive asyn\u2010SAA at baseline related to longitudinal diagnosis reinforcement. Clinical scales and neurofilament light chain (NfL) predicted shorter survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Quantitative oculometry and negative\/low\u2010fluorescence\u2010positive CSF asyn\u2010SAA predict diagnostic validation in so\u2010PSP. In probable\/possible\u2010PSP, positive CSF asyn\u2010SAA may suggest copathology, although confirmation requires larger pathological studies. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70086","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:28:53Z","timestamp":1761762533000},"page":"500-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Barcelona Progressive Supranuclear Palsy (\n                    <scp>PSP)<\/scp>\n                    Registry: Clinical, Oculomotor, and Cerebrospinal Fluid Markers; from Suggestive to Definite Cases"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-3093","authenticated-orcid":false,"given":"Celia","family":"Painous","sequence":"first","affiliation":[{"name":"Unitat de Parkinson i altres Trastorns del Moviment, Servei de Neurologia, Hospital Cl\u00ednic de Barcelona; 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