{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:21:05Z","timestamp":1791048065653,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG064803"],"award-info":[{"award-number":["R01AG064803"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008440","name":"International Parkinson and Movement Disorder Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Predicting initiation of dopaminergic therapy in early Parkinson's disease (\n PD<\/jats:styled-content>\n ) is important for clinical management and trial design. Prior cross\u2010sectional work identified a six\u2010item patient\u2010reported subset from the Movement Disorder Society\u2010sponsored revision of the Unified Parkinson's Disease Rating Scale (\n MDS<\/jats:styled-content>\n \u2010\n UPDRS)<\/jats:styled-content>\n Parts\n IB<\/jats:styled-content>\n \u2009+\u2009\n II<\/jats:styled-content>\n , but its longitudinal utility is unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To test whether modeling longitudinal symptom trajectories improves prediction of dopaminergic therapy initiation beyond baseline\u2010only models, and to identify an abbreviated patient\u2010reported subset with stable prognostic value and utility for trial stratification.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data were harmonized from 1787 untreated early\n PD<\/jats:styled-content>\n patients across six multicenter studies. All 20\n MDS<\/jats:styled-content>\n \u2010\n UPDRS<\/jats:styled-content>\n Parts\n IB<\/jats:styled-content>\n \u2009+\u2009\n II<\/jats:styled-content>\n items were analyzed using a longitudinal item response theory model. Items were ranked by discrimination and information functions, and cumulative subsets evaluated in Cox models with time\u2010dependent covariates, adjusted for age, sex, disease duration, and Hoehn and Yahr stage. Predictive accuracy was quantified by concordance index (C\u2010index) for full follow\u2010up and truncation at 1 and 2\u2009years. Risk stratification was assessed based on baseline abbreviated subset scores using Kaplan\u2013Meier analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n An 11\u2010item model consistently outperformed the full 20\u2010item scale (C\u2010index 0.609 vs. 0.597,\n P<\/jats:italic>\n \u2009<\u20090.001 with full follow\u2010up; 0.621 vs. 0.599,\n P<\/jats:italic>\n \u2009<\u20090.001 at 1\u2009year; 0.615 vs. 0.602,\n P<\/jats:italic>\n \u2009<\u20090.001 at 2\u2009years). Longitudinal updates improved discrimination over baseline\u2010only models (eg, 0.609 vs. 0.594 for full follow\u2010up). Higher baseline 11\u2010item scores were strongly associated with earlier therapy initiation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Longitudinal symptom modeling improves prediction of therapy initiation in early\n PD<\/jats:styled-content>\n . An abbreviated 11\u2010item patient\u2010reported\n MDS<\/jats:styled-content>\n \u2010\n UPDRS<\/jats:styled-content>\n provides stronger prognostic value than the full scale and supports trial stratification and clinical monitoring. \u00a9 2025 International Parkinson and Movement Disorder Society.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.70096","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T13:19:53Z","timestamp":1761657593000},"page":"426-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal Evaluation of an Abbreviated Patient\u2010Reported Movement Disorder Society\u2010sponsored revision of the Unified Parkinson's Disease Rating Scale (\n MDS<\/scp>\n \u2010\n UPDRS)<\/scp>\n for Predicting Dopaminergic Therapy Initiation in Early Parkinson's Disease"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0602-5861","authenticated-orcid":false,"given":"Mohammad Samsul","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Biostatistics & Bioinformatics Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luowen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics & Bioinformatics Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn T.","family":"Stebbins","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6973-7479","authenticated-orcid":false,"given":"Tiago A.","family":"Mestre","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Ottawa Hospital Research Institute University of Ottawa Brain and Mind Research Institute University of Ottawa, The Ottawa Hospital Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Goetz","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4214-5809","authenticated-orcid":false,"given":"Sheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics & Bioinformatics Duke University Durham North Carolina 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