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Digital health technologies (DHT) offer an objective continuous assessment of motor symptoms and are increasingly used in clinical research. This review evaluated the role of DHTs as outcome tools in pharmacological trials for PD. A systematic search of MEDLINE and Embase was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses) guidelines, covering studies up to August 31, 2025. Eligible studies included randomized controlled trials, open\u2010label or crossover designs, and observational studies using DHTs to assess motor outcome variables in PD. Studies focusing only on technology development or with fewer than 10 participants were excluded. Data extracted included study design, DHT type, assessment setting, and motor parameters measured. Study quality was appraised using an eight\u2010criterion tool, and level of evidence was rated using the Oxford Centre for Evidence\u2010Based Medicine framework. A total of 42 studies were included, covering 26 distinct DHTs. These comprised 11 wearable sensors and 15 nonwearable systems such as motion capture platforms and force\u2010sensing assessments. DHTs were used to measure bradykinesia, tremor, gait, balance, and nocturnal motor symptoms in both supervised and unsupervised settings. Fifteen studies were rated as high quality, 14 moderate, and 13 low. Among currently available tools, only Opal reached the threshold of Level 1a evidence. Other validated tools included the Parkinson's Kinetigraph, Actiwatch, and Roche PD Mobile Application (Level 1b). DHTs offer valuable tools for objective assessment in PD trials, though broader adoption requires greater standardization and regulatory alignment. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.70097","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:14:24Z","timestamp":1761992064000},"page":"40-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Assessing Digital Health Technologies for Outcome Measurement in Parkinson's Disease Drug Trials: A Systematic Review"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-164X","authenticated-orcid":false,"given":"Sasivimol","family":"Virameteekul","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4157-492X","authenticated-orcid":false,"given":"Chaewon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital  Seongnam\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-8837","authenticated-orcid":false,"given":"Siegfried S.","family":"Hirczy","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Texas Southwestern  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini","family":"Sarva","sequence":"additional","affiliation":[{"name":"Department of Neurology, Parkinson's Disease and Movement Disorders Institute Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serene S.","family":"Paul","sequence":"additional","affiliation":[{"name":"Sydney School of Health Sciences, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Maetzler","sequence":"additional","affiliation":[{"name":"Department of Neurology Kiel University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-2292","authenticated-orcid":false,"given":"Anat","family":"Mirelman","sequence":"additional","affiliation":[{"name":"Laboratory for Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Medical Center, Sagol School of Neuroscience and Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-4041","authenticated-orcid":false,"given":"Ruth B.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Hausdorff","sequence":"additional","affiliation":[{"name":"Laboratory for Early Markers of Neurodegeneration, Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Medical Center, Sagol School of Neuroscience and Gray Faculty of Medicine and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Rush Alzheimer's Disease Center and Department of Orthopedic Surgery Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-4774","authenticated-orcid":false,"given":"Joaquin A.","family":"Vizcarra","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Klucken","sequence":"additional","affiliation":[{"name":"Department of Digital Medicine Luxembourg Centre for Systems Biomedicine, University of Luxembourg  Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0730-4061","authenticated-orcid":false,"given":"Mariana H.G.","family":"Monje","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Parkinson's Disease and Movement Disorders Center Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4532-3984","authenticated-orcid":false,"given":"Martina","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Neurology Oregon Health &amp; 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