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Biomarkers indicative of ongoing immune dysregulation could potentially serve as early indicators of disease activity and may support the development of novel immunomodulatory therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a meta\u2010analysis on 17 biomarkers related to specific components of the neuroinflammatory response in the cerebrospinal fluid of people with PD (PwP) and controls. We included studies that measured biomarkers related to NLRP3 inflammasome priming and activation (interleukin [IL]\u20101\u03b2, IL\u201018, IL\u20106, C\u2010reactive protein, tumor necrosis factor [TNF]\u2010\u03b1); reactive glial cells (soluble triggering receptor expressed on myeloid cells 2, chitinase 3\u2010like\u2010protein 1, glial fibrillary acidic protein, and s100); neurodegeneration (neurofilament light chain [NfL]); and other inflammatory mediators (interferon\u2010\u0263, IL\u20102, IL\u20104, IL\u20108, IL\u201010, monocyte chemoattractant protein\u20101, chemokine C\u2010X3\u2010C motif chemokine ligand 1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Random\u2010effects meta\u2010analyses show markers downstream of the NLRP3 inflammasome priming and activation (IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1), the astrocytic marker s100 calcium\u2010binding protein B and neuroaxonal damage marker NfL are significantly increased in the cerebrospinal fluid (CSF) of PwP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The elevation in key downstream and general inflammatory mediators results is consistent with the hypothesized involvement of the NLRP3 inflammasome pathway and neurodegeneration in PD pathogenesis. These results highlight the potential use of CSF inflammatory markers and support further investigation into immunomodulatory strategies for PD. \u00a9 2025 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70103","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:56:12Z","timestamp":1764420972000},"page":"466-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>Cerebrospinal Fluid<\/scp>\n                    Biomarkers of\n                    <scp>NLRP3<\/scp>\n                    Pathway, Immune Dysregulation, and Neurodegeneration in Parkinson's Disease: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"41","author":[{"given":"Alina\u2010M\u0103riuca","family":"Marinescu","sequence":"first","affiliation":[{"name":"Roche Pharma Research and Early Development NRD Biomarkers, Roche Innovation Center Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venissa","family":"Machado","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development NRD Biomarkers, Roche Innovation Center Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Pagano","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development NRD Early Clinical Development, Roche Innovation Center Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta Milani","family":"Muelhardt","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development NRD Portfolio Development, Roche Innovation Center Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kustermann","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development NRD Biomarkers, Roche Innovation Center Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Zsuzsanna","family":"Mracsko","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development NRD Research, Roche Innovation Center Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7515-8596","authenticated-orcid":false,"given":"Kathrin","family":"Brockmann","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Shariati","sequence":"additional","affiliation":[{"name":"F. 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