{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:01Z","timestamp":1786978261994,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disorder with prominent upper limb tremors. No trials have evaluated tremor\u2010targeted therapies in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated long\u2010acting propranolol for efficacy and safety in reducing tremors and improving ataxia and quality of life in SCA12.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center, randomized, double\u2010blind, placebo\u2010controlled trial, 60 genetically confirmed SCA12 patients (aged 18\u201365\u2009years; TETRAS PS [The Essential Tremor Rating Assessment Scale Performance Subscale] upper limb component \u22652) were randomized 1:1 to receive extended\u2010release propranolol or placebo. Propranolol was escalated by 40\u2009mg\/week (placebo by one tablet\/week) up to 240\u2009mg\/day, limiting side effects or \u226530% reduction in TETRAS PS\/ADL (Activities\u2010of\u2010Daily\u2010Living Subscale)\u2009+\u2009PS. The stable dose was continued for 8\u2009weeks (maintenance phase). Primary outcomes were changes from baseline in TETRAS PS and ADL\u2009+\u2009PS at maintenance weeks 4 and 8. Secondary outcomes included changes in the Scale for the Assessment and Rating of Ataxia (SARA), RAND 36\u2010Item Short\u2010Form Health Survey (SF\u201036) domains, and accelerometric tremor parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Propranolol significantly reduced TETRAS PS (LSM\u2009\u00b1\u2009SE: \u22124.4\u2009\u00b1\u20090.3 at week 4; \u22124.42\u2009\u00b1\u20090.4 at week 8) and ADL\u2009+\u2009PS (\u22125.5\u2009\u00b1\u20090.63 at week 4; \u22125.56\u2009\u00b1\u20090.62 at week 8;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001 vs. placebo). Significant improvements were also noted in SARA and five of nine SF\u201036 domains at both time points. Accelerometry confirmed reductions in tremor peak frequency and power in all positions except rest. Fatigue and headache were the commonest adverse effects, with no discontinuations due to adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Propranolol effectively reduced tremors and improved quality of life in SCA12, with good tolerability. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70115","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T07:12:52Z","timestamp":1763622772000},"page":"373-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Propranolol for Tremors in Spinocerebellar Ataxia Type 12: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-0152","authenticated-orcid":false,"given":"Prachi","family":"Mohapatra","sequence":"first","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-7947","authenticated-orcid":false,"given":"Achal","family":"Kumar Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-3370","authenticated-orcid":false,"given":"Divyani","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-1961","authenticated-orcid":false,"given":"Ayush","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-7398","authenticated-orcid":false,"given":"Divya M.","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awadh Kishor","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahaj","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Datt","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Clinical Research Unit All India Institute of Medical Sciences  New Delhi 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