{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:01:43Z","timestamp":1791910903360,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS107131"],"award-info":[{"award-number":["NS107131"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fragile X\u2010associated tremor\/ataxia syndrome (FXTAS) is a neurodegenerative disorder marked by white matter degeneration and intranuclear inclusions. While astrocytic and neuronal inclusions are well\u2010documented, oligodendrocytes were previously thought to lack such pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To demonstrate that oligodendrocytes in the prefrontal cortex of FXTAS patients do harbor intranuclear inclusions, with significantly higher burden in white matter than gray matter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ubiquitin and p62 immunofluorescence and enzymatic staining were employed to confirm the presence of intranuclear inclusions in oligodendrocytes across multiple brain regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Oligodendrocytes contain inclusions and inclusion burden is correlated with\n                      <jats:italic>FMR1<\/jats:italic>\n                      CGG repeat length (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.97,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) in white matter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings implicate oligodendrocyte dysfunction in FXTAS pathogenesis which may contribute to demyelination and white matter degeneration. Our data emphasize the need to consider cell type\u2010specific mechanisms in FXTAS and support future therapeutic efforts aimed at restoring glial proteostasis. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70145","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:58:00Z","timestamp":1765011480000},"page":"1041-1046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oligodendrocyte Inclusion Pathology in Fragile X\u2010Associated Tremor\/Ataxia Syndrome"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8272-2012","authenticated-orcid":false,"given":"Yingratana","family":"McLennan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine University of California Davis Health  Sacramento California USA"},{"name":"Institute for Pediatric Regenerative Medicine and Shriners Hospital for Children  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Aliashrafzadeh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine University of California Davis Health  Sacramento California USA"},{"name":"Institute for Pediatric Regenerative Medicine and Shriners Hospital for Children  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith","family":"Zirkelbach\u2010Ngai","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine University of California Davis Health  Sacramento California USA"},{"name":"Institute for Pediatric Regenerative Medicine and Shriners Hospital for Children  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forrest","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Institute for Pediatric Regenerative Medicine and Shriners Hospital for Children  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett D.","family":"Dufour","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine University of California Davis Health  Sacramento California USA"},{"name":"Institute for Pediatric Regenerative Medicine and Shriners Hospital for Children  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina V.","family":"Becerra\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Estudios Cerebrales, Facultad de Salud Universidad del Valle  Cali Colombia"},{"name":"Departamento de Ciencias B\u00e1sicas de la Salud Pontificia Universidad Javeriana  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo Sanchez","family":"Escobar","sequence":"additional","affiliation":[{"name":"Centro de Estudios Cerebrales, Facultad de Salud Universidad del Valle  Cali Colombia"},{"name":"Cl\u00ednica Imbanaco Grupo Quir\u00f3nsalud  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, School of Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hagerman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, School of Medicine University of California, Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"Hagerman","sequence":"additional","affiliation":[{"name":"Medical 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