{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:01:16Z","timestamp":1790348476315,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Friedreich's ataxia (FA) is a neurodegenerative disorder often accompanied by respiratory dysfunction, but detailed respiratory profiles remain understudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate pulmonary parameters and respiratory muscle strength in individuals with FA compared with healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixteen FA patients and 20 age\u2010matched healthy controls underwent spirometry, maximal inspiratory and expiratory pressure measurements, sniff nasal inspiratory pressure (SNIP), phrenic nerve conduction study, peripheral oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ), and end\u2010tidal CO2 (ETCO2). Respiratory parameters were analyzed using Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test or Mann\u2013Whitney test, and linear or quantile regression adjusted for body mass index and smoking status. Ataxia severity was assessed using the Scale for the Assessment and Rating of Ataxia (SARA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FA patients exhibited significantly reduced forced vital capacity (FVC) and forced expiratory volume in 1\u2009s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ), alongside decreased maximal respiratory pressures (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). A restrictive ventilatory pattern predominated. Peripheral oxygen saturation was lower in the FA group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Respiratory impairment appears mostly subclinical, suggesting that FA patients may be vulnerable to pulmonary infections and ventilatory failure. This dysfunction may reflect both neuromuscular weakness and impaired respiratory coordination. Early and regular respiratory assessment, together with preventive and rehabilitative strategies integrated into multidisciplinary care, may improve quality of life and potentially prolong survival in individuals with FA. \u00a9 2025 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70162","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:14:36Z","timestamp":1766153676000},"page":"921-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory Function in Friedreich's Ataxia"],"prefix":"10.1002","volume":"41","author":[{"given":"Celiana Figueiredo","family":"Viana","sequence":"first","affiliation":[{"name":"Division of General Neurology and Ataxia Unit, Department of Neurology Universidade Federal de S\u00e3o Paulo\u2010Escola Paulista de Medicina  S\u00e3o Paulo 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