{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:01:16Z","timestamp":1790348476242,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01 NS115658"],"award-info":[{"award-number":["U01 NS115658"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent advances in proteomic profiling have enabled its use as a powerful approach in elucidating molecular mechanisms underlying Parkinson's disease, enabling the identification of disease\u2010associated protein alterations and candidate biomarkers for diagnosis, progression, and therapeutic response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The Accelerating Medicines Partnership\u00ae Parkinson's Disease (AMP PD) program is a public\u2013private partnership between the National Institutes of Health (NIH), multiple biopharmaceutical and life sciences companies, and non\u2010profit organizations, managed by the Foundation for National Institutes of Health (FNIH). The program aims to advance the molecular and clinical characterization of PD through deep, longitudinal profiling of patient data and biosamples, with the goal of identifying and validating diagnostic, prognostic, and progression biomarkers for PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Longitudinal proteomic profiling, both targeted and untargeted, was performed on cerebrospinal fluid (CSF) and plasma samples. The resulting datasets are publicly accessible via the AMP\u00ae PD Knowledge Platform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proteomic datasets enable differential protein analyses and can be used to explore molecular alterations associated with PD progression and heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These studies contribute to the broader AMP PD initiative by providing the research community with a harmonized proteomics dataset. As part of the larger AMP PD data, this work provides the PD community with a harmonized and accessible proteomics dataset that can be utilized for discovery, hypothesis generation, and validation of users\u2019 own research. \u00a9 2026 Technome.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70183","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:59:53Z","timestamp":1770289193000},"page":"972-980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Accelerating Medicines Partnership\u00ae Parkinson's Disease Proteomics: A Comprehensive Resource for Advancing Parkinson's Disease Research"],"prefix":"10.1002","volume":"41","author":[{"given":"Victoria J.","family":"Dardov","sequence":"first","affiliation":[{"name":"Technome  Herndon Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Vasanthakumar","sequence":"additional","affiliation":[{"name":"AbbVie  North Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameya","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"AbbVie  North Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niveda","family":"Sundararaman","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhi","family":"Pandey","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1582-8430","authenticated-orcid":false,"given":"Preeti","family":"Bais","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9050-148X","authenticated-orcid":false,"given":"Jennifer E.","family":"Van","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Quinton","sequence":"additional","affiliation":[{"name":"AbbVie  North Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Landin","sequence":"additional","affiliation":[{"name":"Technome  Herndon Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Vismer","sequence":"additional","affiliation":[{"name":"Technome  Herndon Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford","family":"Casey","sequence":"additional","affiliation":[{"name":"The Michael J. Fox Foundation for Parkinson's Research  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Bookman","sequence":"additional","affiliation":[{"name":"Verily Life Sciences  San Jose California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy","family":"Nojopranoto","sequence":"additional","affiliation":[{"name":"Verily Life Sciences  San Jose California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-1522","authenticated-orcid":false,"given":"Erin","family":"Teeple","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Kayatekin","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaraman","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Hargreaves","sequence":"additional","affiliation":[{"name":"Neuroscience Thematic Research Center, Bristol Myers Squibb  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guhan","family":"Nagappan","sequence":"additional","affiliation":[{"name":"Glaxo Smith Kline  Collegeville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Pablo","family":"Sardi","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Ramulu","family":"Pullagura","sequence":"additional","affiliation":[{"name":"Foundation for the National Institutes of Health  North Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Swanson\u2010Fischer","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Accelerating Medicines Partnership Parkinson's Disease (AMP PD) Proteomics Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/4454744"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2022.2070477"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00586"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2022.101556"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00218-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30320-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201300342"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00517-w"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12813"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.0c00747"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101514"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00080"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100661"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00461-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02706-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03834-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06592-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aam6003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207725"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914915"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29257"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42834-x"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.70183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.70183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:20:11Z","timestamp":1790346011000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.70183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/mds.70183"],"URL":"https:\/\/doi.org\/10.1002\/mds.70183","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"2025-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}