{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:00:46Z","timestamp":1784689246406,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010NS89757)"],"award-info":[{"award-number":["R01\u2010NS89757)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The cerebellar dentate is a known site of iron accumulation and tau deposition in progressive supranuclear palsy (PSP); however, detailed iron distribution and localized volume and shape changes remain unclear across PSP clinical variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The study aimed to clarify details about regional susceptibility distribution, volume, and shape deformation in the cerebellar dentate across PSP clinical variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010seven PSP patients, including 31 PSP\u2010Richardson syndrome, 12 PSP\u2010parkinsonism, 10 PSP\u2010progressive gait freezing, and 14 PSP\u2010cortical variants (PSP\u2010frontal, PSP\u2010speech\/language, and PSP\u2010corticobasal syndrome), and 31 healthy controls underwent 3\u2009Tesla magnetic resonance imaging to reconstruct quantitative susceptibility maps. Manual dentate segmentation was performed to extract magnetic susceptibility and volume adjusted for total intracranial volume. Shape deformation was assessed using Deformetrica atlas construction. Group comparisons were evaluated with Kruskal\u2013Wallis tests and receiver operating characteristic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with PSP\u2010Richardson syndrome, PSP\u2010parkinsonism, and PSP\u2010cortical variants showed significantly increased dentate susceptibility compared with controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Patients with PSP\u2010progressive gait freezing showed no significant susceptibility differences. Volume loss was most prominent in PSP\u2010cortical variants, bilaterally, and PSP\u2010Richardson syndrome, left hemisphere only (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Shape analysis revealed subregion\u2010specific deformation patterns, especially in the anterior and posterior deformation in PSP\u2010progressive gait freezing and the ventroanterior deformation in PSP\u2010cortical variants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PSP clinical variants had different patterns of susceptibility, volume, and shape metrics, reflecting distinct neurodegenerative patterns of the cerebellar dentate. These findings contribute to our understanding of the neurobiology of PSP and may help to improve phenotypic differentiation of PSP clinical variants. \u00a9 2026 International Parkinson and Movement Disorder Society.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70204","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:04:04Z","timestamp":1768993444000},"page":"1233-1243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Localized Iron Deposition and Shape Changes of Cerebellar Dentate in Progressive Supranuclear Palsy Clinical Variants"],"prefix":"10.1002","volume":"41","author":[{"given":"Austin C.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota 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