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The locus coeruleus (LC) is also affected in Parkinson's disease and linked to some nonmotor symptoms, but the extent and timing of its degeneration remain unclear. Studies in 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2013treated monkeys have reported inconsistent findings ranging from no LC loss to substantial degeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed (1) to determine whether noradrenergic neurons and thalamic noradrenergic axons undergo degeneration in a well\u2010characterized cohort of MPTP\u2010treated monkeys, and (2) to compare the degree of noradrenergic and dopaminergic loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed stereological quantification of noradrenergic neurons in the LC (A5, A6, and A7) and thalamic noradrenergic axons in\n                      <jats:italic>Macaca fascicularis<\/jats:italic>\n                      monkeys (n\u2009=\u200920) representing presymptomatic, recovered, moderate, and severe parkinsonian stages. Noradrenergic neurons and axons were immunostained for dopamine\u2010\u03b2\u2010hydroxylase, quantified, and compared with previous data from dopaminergic SNc neurons in the same animals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Noradrenergic cells were largely preserved, with estimated reductions of 4%, 12%, 3%, and 10% in presymptomatic, recovered, moderate, and severe stages, respectively, in parallel with marked and progressive dopaminergic neuronal loss. Densities of noradrenergic axons in the thalamus of MPTP monkeys did not differ significantly from control levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We found no evidence of noradrenergic neuronal loss and thalamic noradrenergic axon reduction in MPTP monkeys exhibiting severe SNc damage. These findings show significant differences in vulnerability to MPTP between the dopaminergic and noradrenergic systems. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70209","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:25:33Z","timestamp":1770895533000},"page":"1197-1208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative Analysis of Locus Coeruleus Neurons and Thalamic Noradrenergic Axons in a Progressive 1\u2010Methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine Monkey Model of Parkinson's Disease"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6864-1551","authenticated-orcid":false,"given":"Megan","family":"Carrillo","sequence":"first","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales  Madrid Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4915-1598","authenticated-orcid":false,"given":"Nagore","family":"Hern\u00e1ndez\u2010Pinedo","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales  Madrid 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