{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:17:46Z","timestamp":1783361866592,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPJS00420240019"],"award-info":[{"award-number":["JPJS00420240019"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH20FC1041"],"award-info":[{"award-number":["JPMH20FC1041"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP256f0137005"],"award-info":[{"award-number":["JP256f0137005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP266f0137005"],"award-info":[{"award-number":["JP266f0137005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP276f0137005"],"award-info":[{"award-number":["JP276f0137005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25wm0625520"],"award-info":[{"award-number":["JP25wm0625520"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alterations in tryptophan\u2013kynurenine (TRP\u2010KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 51 patients with MSA and 56 controls were included. CSF TRP metabolites, such as KYN, quinolinic acid (QA), and kynurenic acid (KA), along with neurofilament light chain (NfL), glycoprotein nonmetastatic melanoma protein B (GPNMB), and soluble triggering receptor expressed on myeloid cells 2 (sTREM2), were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with MSA exhibited higher levels of QA, a neuroinflammatory marker, and lower levels of KA, a neuroprotective marker, yielding an elevated QA\u2010to\u2010KA ratio. Neither QA nor KA correlated with clinical scores. GPNMB, sTREM2, and NfL were increased; however, these markers were independent of KYN pathway metabolites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      MSA exhibited a significant imbalance in KYN metabolism, suggesting a shift toward inflammatory processes distinct from classic neuroinflammatory markers. \u00a9 2026 The Author(s).\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.70210","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T10:22:17Z","timestamp":1770027737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Altered Cerebrospinal Fluid Tryptophan\u2013Kynurenine Pathway Metabolism in Multiple System Atrophy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4412-3892","authenticated-orcid":false,"given":"Ryunosuke","family":"Nagao","sequence":"first","affiliation":[{"name":"Department of Neurology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-4377","authenticated-orcid":false,"given":"Kazuya","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Division of BrainTheraInformatics, International Center for Brain Science (ICBS) Fujita Health University  Toyoake Japan"},{"name":"Fujita Mind\u2010Brain Research &amp; Innovation Center for Drug Generation (Fujita Mind\u2010BRIDGe) International Center for Brain Science (ICBS), Fujita Health University  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-8526","authenticated-orcid":false,"given":"Yasuaki","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Department of Neurology Fujita Health University Okazaki Medical Center  Okazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Department of Neurology Fujita Health University Bantane Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Maeda","sequence":"additional","affiliation":[{"name":"Open Facility Center Fujita Health University  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Mouri","sequence":"additional","affiliation":[{"name":"Fujita Mind\u2010Brain Research &amp; Innovation Center for Drug Generation (Fujita Mind\u2010BRIDGe) International Center for Brain Science (ICBS), Fujita Health University  Toyoake Japan"},{"name":"Department of Regulatory Science for Evaluation &amp; Development of Pharmaceuticals &amp; Devices Fujita Health University Graduate School of Medical Sciences  Toyoake Japan"},{"name":"Division of Neurochemistry, ICBS Fujita Health University  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-8536","authenticated-orcid":false,"given":"Hirohisa","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Neurology Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Fujita Mind\u2010Brain Research &amp; Innovation Center for Drug Generation (Fujita Mind\u2010BRIDGe) International Center for Brain Science (ICBS), Fujita Health University  Toyoake 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